2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. His-TERRα

His-TERRα 是一种 ERRα PROTAC 降解剂。His-TERRα 将单个氨基酸 (His) 作为 E3 连接酶配体，利用 N-end rule 通路来诱导目标蛋白降解，显著减小了分子尺寸，因此被称为 mini-PROTAC。His-TERRα 显著抑制 MCF7 乳腺癌细胞的增殖和迁移。His-TERRα 可用于研究乳腺癌。
(粉色: ERRα 靶蛋白配体；蓝色: Ligands for E3 Ligase 配体 (HY-N0832)；黑色: 连接子)。

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His-TERRα

His-TERRα Chemical Structure

CAS No. : 2408835-49-2

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His-TERRα 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

His-TERRα is a ERRα PROTAC degrader. His-TERRα uses a single amino acid (His) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, and thus is called a mini-PROTAC. His-TERRα significantly inhibits the proliferation and migration of MCF7 breast cancer cells. His-TERRα can be used for the study of breast cancer[1]. (Pink: ERRα Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-N0832); Black: linker).

IC50 & Target[1]

ERRα

 

分子量

695.67

Formula

C31H28F3N9O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

His-TERRα 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

His-TERRα2408835-49-2PROTACsEstrogen Receptor/ERRPROTACN-end rule pathwayDegronmini-PROTACLinker-freeAmino acidsUbiquitin ligaseInhibitorinhibitorinhibit

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