2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HTI-1511 Antibody

HTI-1511 Antibody  (Synonyms: Halozyme patent anti-EGFR)

目录号: HY-P991968
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技术支持

HTI-1511 Antibody 是一种靶向 EGFR 的单克隆抗体抑制剂。HTI-1511 Antibody 可用于合成新型抗 EGFR-ADC--HTI-1511。HTI-1511 Antibody 可用于头颈部鳞状细胞癌、非小细胞肺癌、胰腺癌、结直肠癌、肾细胞癌以及表皮样癌的相关研究。

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HTI-1511 Antibody

HTI-1511 Antibody Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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HTI-1511 Antibody 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HTI-1511 Antibody is a monoclonal antibody inhibitor targeting EGFR. HTI-1511 Antibody can be used to synthesize a novel anti-EGFR-ADC, HTI-1511. HTI-1511 Antibody can be used in the research of head and neck squamous cell carcinoma, non-small cell lung cancer, pancreatic cancer, colorectal cancer, renal cell carcinoma, and epidermoid carcinoma[1].

反应种属

Human
体外研究
(In Vitro)

HTI-1511 可强效抑制 SCC15、CAL27、FaDu、CAL33、SCC25、HCC827、NCI-H1666、PC-9、NCI-H1650、BxPC-3、PANC-1 和 AsPC-1 细胞系的体外生长，其 IC50 值范围为 0.04 nM 至 6.2 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HTI-1511 Antibody 相关抗体:
体内研究
(In Vivo)

HTI-1511 (3.0 mg/kg; weekly; up to 8 weeks) 在人源 A431 表皮样癌异种移植模型中实现 93%的肿瘤生长抑制，且未观察到毒性[1]。
HTI-1511 (3.0 mg/kg; weekly; up to 8 weeks) 在人源 BxPC3 胰腺癌异种移植模型中实现了超过 100% 的肿瘤生长抑制，且未观察到毒性[1]。
HTI-1511 (3.0 mg/kg; weekly; up to 8 weeks) 在人源 AsPC-1 胰腺癌异种移植物中实现了超过 100% 的肿瘤生长抑制，且未观察到毒性[1]。
HTI-1511 (1.0-3.0 mg/kg; weekly) 在 KRAS 突变型非小细胞肺癌患者来源异种移植物中实现了超过 100%的肿瘤生长抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

1956  [NCBI]

Accession
靶点

ERBB1/EGFR/HER1
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HTI-1511 Antibody 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HTI-1511 AntibodyHalozyme patent anti-EGFREGFREpidermal growth factor receptorErbB-1HER1head and neck squamous cell carcinomaepidermoid carcinomatumor microenvironmentsolid tumor cellsnon-small cell lung cancerpancreatic carcinomaMMAEcolorectal cancerrenal cell carcinomaInhibitorinhibitorinhibit

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