2. Others
  3. Others
  4. Hydrazinocurcumin

Hydrazinocurcumin (Curcumin pyrazole) 是一种强效的内皮细胞增殖抑制剂 (IC50=520 nM)。Hydrazinocurcumin 会破坏血管生成信号通路，并抑制内皮细胞的迁移和管状结构的形成，发挥抗血管生成的作用。Hydrazinocurcumin 有望用于肿瘤血管生成抑制、转移性癌症以及血管相关疾病 (如视网膜病变) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Hydrazinocurcumin

Hydrazinocurcumin Chemical Structure

CAS No. : 131068-23-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Hydrazinocurcumin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 IC50
19.4 μM
Compound: 1
Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography
Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography
[PMID: 19128977]
Ehrlich ED50
100 mM
Compound: 10
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
10.1007/s00044-009-9199-3
HaCaT IC50
16.2 μM
Compound: 5
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay
[PMID: 24920381]
LNCaP IC50
3.4 μM
Compound: 12
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
[PMID: 19249204]
LNCaP IC50
> 50 μM
Compound: 5
Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay
[PMID: 24920381]
MCF-10A IC50
> 50 μM
Compound: 12
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
[PMID: 19249204]
MCF7 IC50
4.19 μM
Compound: 12
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay
[PMID: 19019687]
MCF7 IC50
5.9 μM
Compound: 12
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 19249204]
MDA-MB-231 IC50
6.6 μM
Compound: 12
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 19249204]
PBMC IC50
> 50 μM
Compound: 5
Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay
[PMID: 24920381]
PC-3 IC50
5.6 μM
Compound: 12
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 19249204]
SK-BR-3 IC50
0.258 μM
Compound: 12
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay
[PMID: 19019687]
分子量

364.39

Formula

C21H20N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hydrazinocurcumin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrazinocurcumin131068-23-0Curcumin pyrazoleOthersendothelial cell proliferationVEGF/VEGFR2metastatic cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Hydrazinocurcumin
目录号：
HY-122757
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z