2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HYNIC-H6F

HYNIC-H6F 是一种 SPECT 成像探针，对人表皮生长因子受体 2 (HER2) 结构域 II 具有结合特异性 ( IC50 = 11 nM)。HYNIC-H6F 可通过受体介导的摄取在 HER2 阳性乳腺癌异种移植物中富集，而在 HER2 阴性乳腺癌异种移植物中的摄取量较低。HYNIC-H6F 能够在小鼠模型中无创检测 HER2 阳性乳腺癌，并可在无封闭干扰的情况下评估 HER2 的表达水平。HYNIC-H6F 可用于乳腺癌相关研究。

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Custom Peptide Synthesis

HYNIC-H6F

HYNIC-H6F Chemical Structure

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HYNIC-H6F 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HYNIC-H6F is a SPECT imaging probe with binding specificity for human epidermal growth factor receptor 2 (HER2) domain II (IC50 = 11 nM). HYNIC-H6F accumulates in HER2-positive breast cancer xenografts via receptor-mediated uptake, while shows low uptake in HER2-negative breast cancer xenografts. HYNIC-H6F enables non-invasive detection of HER2-positive breast cancer in mouse models and allows evaluation of HER2 expression levels without blocking interference. HYNIC-H6F can be used in breast cancer-related research[1].

IC50 & Target[1]

HER2

11 nM (IC50)

体外研究
(In Vitro)

HYNIC-H6F (11 nM; 2 h) 可与 MDA-MB-453 细胞上的 HER2 特异性结合，其 IC50 为 11 nM，且 HYNIC 偶联对结合亲和力的影响极小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HYNIC-H6F 相关抗体:
体内研究
(In Vivo)

99mTc-HYNIC-H6F (0.37-37 MBq；经尾静脉静脉注射；单次给药) 可在 HER2 阳性 MDA-MB-453 乳腺癌异种移植物中特异性聚集，注射后 30 min 时成像定量摄取量达到峰值 3.58 %ID/g，其结合可被过量未标记的 H6F 阻断[1]。
99mTc-HYNIC-H6F (0.37-37 MBq；尾静脉注射；单次给药) 在 HER2 阴性 MDA-MB-231 乳腺癌异种移植物中的蓄积量极低，注射后 30 min 时经生物分布定量的摄取量为 0.99 %ID/g，显著低于其在 HER2 阳性肿瘤中的摄取量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1255.42

Formula

C64H82N14O13
Sequence

{HYNIC}-Tyr-Leu-Phe-Phe-Val-Phe-Glu-Arg
Sequence Shortening

{HYNIC}-YLFFVFER
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HYNIC-H6F 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HYNIC-H6FEGFREpidermal growth factor receptorErbB-1HER1HER2-positive breast cancer xenograftsHER2 domain IIhuman epidermal growth factor receptor 2MDA-MB-231 breast cancer xenograftsMDA-MB-453 cellsHER2-negative breast cancer xenograftsmouse modelsInhibitorinhibitorinhibit

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