2. Immunology/Inflammation GPCR/G Protein
  3. Interleukin Related CXCR
  4. HZD37-5

HZD37-5 是一种可特异性识别 IL-17A N78 位点的人源化单克隆抗体。HZD37-5 可结合人类和恒河猴的相关靶点，阻断 IL-17 诱导的信号转导，以及 IL-6、IL-8、CXCL-1 和 GM-GSF 的释放。HZD37-5 可显著抑制人源 IL-17A 诱导的角质形成细胞趋化因子分泌。HZD37-5 可用于包括银屑病和银屑病关节炎在内的自身免疫性疾病的研究。

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HZD37-5

HZD37-5 Chemical Structure

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HZD37-5 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

查看 CXCR 亚型特异性产品:

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HZD37-5 is a humanized monoclonal antibody specifically recognizing N78 loci of IL-17A. HZD37-5 binds to human and rhesus monkeys, blocks IL-17 induced signal transduction and the release of IL-6, IL-8, CXCL-1 and GM-GSF. HZD37-5 significantly inhibited human IL-17A induced-keratinocyte chemoattractant secretion. HZD37-5 can be used for the research of autoimmune diseases including psoriasis and psoriatic arthritis[1].

反应种属

Human
IC50 & Target[1]

IL-17A

 

IL-6

 

IL-8

 

体外研究
(In Vitro)

HZD37-5 (0.16-20 nM) 对人源和恒河猴源 IL-17A 均表现出极高的亲和力，对应的 Kd 值分别为 7.4 ± 0.6 pM 和 5.1 pM[1]。
HZD37-5 (4 μg/mL, 24 h) 可强效抑制人 IL-17A 诱导的 HEK Blue IL-17 细胞内的信号转导[1]。
HZD37-5 (0.1-10000 nM; 24 h) 可强效抑制人 IL-17A 诱导的 HFF-1 细胞中促炎介质 IL-6、IL-8、CXCL-1 和 GM-CSF 的释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HZD37-5 相关抗体:

ELISA Assay[1]

Cell Line: HFF-1 cells
Concentration: 0.1-10000 nM
Incubation Time: 24 h
Result: Reduced IL-6, IL-8, CXCL-1, and GM-CSF levels.
体内研究
(In Vivo)

HZD37-5 (0.1-10.0 mg/kg；眼眶静脉丛注射；单剂量) 可剂量依赖性地抑制人源 IL-17A 诱导的雌性 C57BL/6 小鼠的角质形成细胞趋化因子分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6-8 weeks old)[1]
Dosage: 0.1 mg/kg; 1.0 mg/kg; 10.0 mg/kg
Administration: Orbital venous plexus injection; single dose
Result: Inhibited human IL-17A-induced KC secretion in a dose-dependent manner.
Exhibited statistically significant inhibition at P < 0.01 compared to IL-17A-only controls at 0.1, 1 and 10 mg/kg.
基因 ID

3605  [NCBI]

Accession
靶点

CTLA-8/IL-17a
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HZD37-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HZD37-5Interleukin RelatedCXCRILCXC chemokine receptorsC-X-C motif chemokine receptorsIL-17AIL-6N78 locusG-CSFIL-8CXCL-1rhesus monkey IL-17AHEK Blue IL-17 cellsInterleukin-17Asignal transductionInhibitorinhibitorinhibit

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