2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1-IN-13

IDO1-IN-13 (compound 27a) 是一种有效的 IDO1 抑制剂，IC50 为 61.6 nM。IDO1-IN-13 具有细胞 IDO1 抑制作用 (HeLa EC50=30 nM)。在 SK-OV-3 异种移植肿瘤组织中，IDO1-IN-13 降低了 51% 的 kyn/trp 比率。

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IDO1-IN-13

IDO1-IN-13 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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IDO1-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC50= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues[1].

IC50 & Target[1]

IDO1

30 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Detroit 551 CC50
> 10 μM
Compound: 27a
Cytotoxicity against human Detroit 551 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human Detroit 551 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 34929581]
分子量

470.34

Formula

C20H16BrN5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-13Indoleamine 2,3-Dioxygenase (IDO)IDO1SK-OV-3 cellsovarianHeLa cellstumor microenvironmentInhibitorinhibitorinhibit

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产品名称：
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目录号：
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