2. Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Indoleamine 2,3-Dioxygenase (IDO) NO Synthase Reactive Oxygen Species (ROS)
  4. IDO1/TDO-IN-11

IDO1/TDO-IN-11 (Compound Y-13) 是一种双重 IDO1 和 TDO 抑制剂，其对 hIDO1 的 IC50 为 2.87 μM，对 hTDO 的 IC50 为 0.08 μM。IDO1/TDO-IN-11 可抑制 NO 生成及 ROS 生成。IDO1/TDO-IN-11 可减轻细胞神经炎症损伤，并改善帕金森病。IDO1/TDO-IN-11 可用于帕金森病的相关研究。

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IDO1/TDO-IN-11

IDO1/TDO-IN-11 Chemical Structure

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IDO1/TDO-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1/TDO-IN-11 (Compound Y-13) is a dual IDO1 and TDO inhibitor, with an IC50 of 2.87 μM against hIDO1 and an IC50 of 0.08 μM against hTDO. IDO1/TDO-IN-11 inhibits NO production and ROS production. IDO1/TDO-IN-11 alleviates cellular neuroinflammatory damage and ameliorates Parkinson's disease. IDO1/TDO-IN-11 is applicable to research related to Parkinson's disease[1].

IC50 & Target[1]

hIDO1

2.87 μM (IC50)

体外研究
(In Vitro)

IDO1/TDO-IN-11 可在无细胞生化分析中强效抑制纯化的 hIDO1 (IC50 = 2.87 ± 0.93 μM) 和 hTDO (IC50 = 0.08 ± 0.01 μM)[1]。
IDO1/TDO-IN-1 可强效抑制 IFN-γ 诱导的 HeLa 细胞中的细胞内 IDO1 活性，其 IC50 为 10.97 ± 1.56 μM[1]。
IDO1/TDO-IN-11 可强效抑制 hTDO 转染 HEK-293 T 细胞中的细胞内 TDO 活性，其 IC50 为 10.34 ± 0.55 μM[1]。
IDO1/TDO-IN-11 (5-80 μM) 可通过浓度依赖性方式抑制 LPS 诱导的 NO 和 ROS 生成，从而保护 BV2 小胶质细胞免受神经炎症损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1/TDO-IN-11 相关抗体:
体内研究
(In Vivo)

IDO1/TDO-IN-11 (25-50 mg/kg；腹腔注射；每日 1 次；连续 14 天) 在 MPTP (HY-W114750) 诱导的帕金森病 (PD) 小鼠模型中表现出保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PD mouse model[1]
Dosage: 25, 50 mg/kg
Administration: i.p.; once daily; 14 days
Result: Significantly prevented the
MPTP-induced deficits.
Had no obvious toxicity.
Reversed PD symptoms at the pathological level (H&E staining of mice brain section).
Improved cognitive function, learning ability, and motor
performance.
分子量

309.32

Formula

C18H15NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1/TDO-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1/TDO-IN-11Indoleamine 2,3-Dioxygenase (IDO)NO SynthaseReactive Oxygen Species (ROS)Nitric oxide synthasesNOSNO generationROS generationparkinson's diseaseHeLa cellshTDOBV2 microglial cellsHEK-293 T cellsneuroinflammationhIDO1tryptophan-kynurenine pathwayInhibitorinhibitorinhibit

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