2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. III-31-C

III-31-C 是一种 (hydroxyethyl)urea γ-secretase 抑制剂。III-31-C 可抑制 Aऔ 的产生，在无细胞 γ-分泌酶测定中 IC50 为 10 nM，在 APP 转染细胞中为 200 nM。III-31-C 可用于阿尔茨海默病研究。

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III-31-C

III-31-C Chemical Structure

CAS No. : 398515-96-3

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III-31-C 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
0.22 μM
Compound: 15
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)
[PMID: 15050631]
CHO IC50
0.4 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA
[PMID: 15588083]
CHO IC50
0.4 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP by ELISA
[PMID: 15588083]
CHO IC50
18 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA
[PMID: 15588083]
HeLa IC50
0.01 μM
Compound: 31c
Inhibition of gamma secretase isolated from HeLa cells by ELISA
Inhibition of gamma secretase isolated from HeLa cells by ELISA
[PMID: 15588083]
分子量

640.81

Formula

C35H52N4O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

III-31-C 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

III-31-C398515-96-3γ-secretaseGamma secretaseHeLaADpresenilincarboxybenzoyl.Inhibitorinhibitorinhibit

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