2. Others Cell Cycle/DNA Damage
  3. Others Topoisomerase
  4. IKE16

IKE16 是一种真菌选择性的真核 topoisomerase II 抑制剂，IC50 值为 13.68 μM。IKE16 选择性地抑制 yTOPOII 的 DNA 松弛活性和解链活性。IKE16 对标准真菌菌株 (Candida albicans ATCC 10231、Saccharomyces cerevisiae ATCC 89763) 显示出适度活性，对 S. cerevisiae ATCC 89763 的最低抑菌浓度 (MIC) 为 2 μg/mL。IKE16 对人体细胞表现出高细胞毒性，在 HepG2 细胞中的 EC50 为 0.07 μM，在 HEK-293 细胞中为 0.045 μM。IKE16 可用于抗真菌感染研究。

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IKE16

IKE16 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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IKE16 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection[1].

IC50 & Target[1]

Topoisomerase II

13.68 μM (IC50)

分子量

644.72

Formula

C36H36N8O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IKE16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKE16IKE 16IKE-16OthersTopoisomerasetopoisomerase IIantifungal infectionHEK-293HepG2Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-178330
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