2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. IKVAVC

IKVAVC 是 IKVAV​ 在 C 端人工添加了一个半胱氨酸 (Cys) 的衍生肽。IKVAVC 保留了原始 IKVAV 的全部生物活性，主要作为神经粘附/分化信号肽，且增添了一个工程化连接臂，从而可以共价连接到分子材料上。IKVAV 抑制成纤维细胞的迁移与激活，下调 TGF-β1 信号通路和内质网应激，促进神经修复。IKVAV 能够调节巨噬细胞表型，使其从促炎的 M1 型向促修复的 M2 型转变。

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Custom Peptide Synthesis

IKVAVC

IKVAVC Chemical Structure

CAS No. : 1187540-64-2

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IKVAVC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKVAVC is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus. IKVAVC retains all the biological activities of the original IKVAV, mainly acting as a neural adhesion/differentiation signaling peptide, and is equipped with an engineered linker arm that enables covalent conjugation to molecular materials. IKVAV inhibits the migration and activation of fibroblasts, downregulates the TGF-β1 signaling pathway and endoplasmic reticulum stress, and promotes nerve repair. IKVAV regulates the phenotype of macrophages, shifting them from the pro-inflammatory M1 type to the pro-reparative M2 type[1][2][3].

体外研究
(In Vitro)

IKVAVC 通过化学反应共价连接到水凝胶、树枝状大分子等生物材料上。这种功能化材料能够长期、稳定地提供生物活性信号，构建出有利于神经再生和血管生成的仿生微环境，在脊髓损伤等疾病的治疗中展现出应用潜力[1][2][3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IKVAVC 相关抗体:
分子量

631.83

Formula

C28H53N7O7S
CAS 号
Sequence

Ile-Lys-Val-Ala-Val-Cys
Sequence Shortening

IKVAVC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IKVAVC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKVAVC1187540-64-2TGF-beta/SmadTransforming growth factor betaneural stem cellpheochromocytoma cellsmacrophageintegrin α2β1PAMAM dendrimersspinal cord injury modelsPLEOF hydrogelsfibroblastbone marrow mesenchymal stem cellchondroitin sulfate proteoglycanInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P11753
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