2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Acyltransferase Phosphatase Interleukin Related
  4. Ilekudinol B

Ilekudinol B 是一种 ACAT 和 PTP1B 抑制剂，其对人源 PTP1B 的 IC50 为 5.3 μM，Ki 为 11.6 μM。Ilekudinol B 可抑制补体系统的经典途径，其 IC50 为 51 μM。Ilekudinol B 抑制 TNF-α 诱导的细胞 IL-8 分泌，促进骨骼肌肌管的葡萄糖摄取，发挥胰岛素模拟剂和胰岛素增敏剂的作用。Ilekudinol B 可用于 2 型糖尿病、肥胖症及炎症性疾病的相关研究。

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Ilekudinol B

Ilekudinol B Chemical Structure

CAS No. : 242794-72-5

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Ilekudinol B 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

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ACAT1 ACAT2 MGAT2 ACAT DGAT1

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases[1][2][3][4].

IC50 & Target

ACAT

 

IL-8

 

体外研究
(In Vitro)

Ilekudinol B (0.1-10 μg/mL) 可抑制 HT29 细胞中 TNF-α 诱导的 IL-8 产生[3]。
Ilekudinol B (1-50 μM；1 h 20 min) 可使 L6 肌管的葡萄糖摄取量在基础状态下提升 1.6 倍、在胰岛素刺激状态下提升 2.9 倍[4]。
Ilekudinol B (1-50 μM；24-48 h) 在高达 50 μM 的浓度下对 L6 成肌细胞无细胞毒性 [4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ilekudinol B 相关抗体:

Cell Cytotoxicity Assay[4]

Cell Line: L6 myoblasts
Concentration: 1-50 μM
Incubation Time: 24 h; 48 h
Result: Showed no significant reduction in cell viability compared to vehicle control at concentrations up to 50 μM after 24 h or 48 h of treatment.
分子量

456.66

Formula

C29H44O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ilekudinol B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilekudinol B242794-72-5AcyltransferasePhosphataseInterleukin RelatedDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseILskeletal muscle myotubesACATHT29 cellsIL-8acyl CoA cholesteryl acyl transferaseprotein tyrosine phosphatase 1Bsheep erythrocytesTNF-αskeletal muscle myoblastsPTP1BInhibitorinhibitorinhibit

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