Indaziflam  (Synonyms: 茚嗪氟草胺)

Indaziflam is an alkyltriazine herbicide. Indaziflam targets the cellulose synthase complex and inhibits cellulose biosynthesis in plant cell walls. Indaziflam induces radial swelling of plants, ectopic lignification, inhibition of root and hypocotyl elongation, abnormal root and cell morphology, and also induces DNA strand breaks and micronucleus formation in HepG2 cells. Indaziflam can be used for research on monocot weed control^[1][2][3].

Indaziflam (500-10000 pM; 7 d) 可强效抑制光下生长的早熟禾 (GR₅₀ = 671 pM)、光下生长的拟南芥 (GR₅₀ = 200 pM) 以及暗下生长的拟南芥 (GR₅₀ = 214 pM) 幼苗的生长，诱导类似纤维素生物合成抑制剂的症状，包括径向膨大与异位木质化^[1]。
Indaziflam (200-400 pM; 5 d) 可剂量依赖性地降低暗培养拟南芥幼苗下胚轴中的结晶纤维素含量^[1]。
Indaziflam (50-3200 pM; 0-84 h) 可以剂量依赖的方式抑制雀麦、野黑麦、拟南芥和地肤幼苗的根伸长及生长速率，且对单子叶植物的效力显著高于双子叶植物 (单子叶植物根长度的平均 GR₅₀ = 231 pM，双子叶植物根长度的平均 GR₅₀ = 512 pM)^[2]。
Indaziflam (200-3200 pM; 84 h) 处理会导致雀麦、野黑麦、拟南芥和地肤的根系出现纤维素缺失及明显的形态异常，在等效浓度下，单子叶植物根系的结构损伤程度重于双子叶植物根系^[2]。
Indaziflam (10-100 μg/mL; 4-24 h) 可在 HepG2 细胞中诱导呈剂量和时间依赖性的 DNA 链断裂^[3]。
Indaziflam (10-100 μg/mL; 4-24 h) 可在 HepG2 细胞中诱导呈剂量和时间依赖性的染色体损伤^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indaziflam (50-3200 pM; 混入培养基；持续暴露; 0.1-11.7 g·ai·ha^-1; 叶面喷雾；单次施用；44-102 g·ai·ha^-1; 叶面喷雾；在指定时间点单次施用) 可实现剂量依赖性的选择性防除，其对入侵性冬季一年生禾本科植物 (单子叶植物) 的防除剂量低于阔叶杂草 (双子叶植物)；在施用后第 2 年，102 g·ai·ha^-1 剂量下对柔枝冰草、野黑麦和日本冰草的防除率达 97%-99%，同时还能促进伴生本土植物的生物量增加和物种丰富度提升^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

301.37

C₁₆H₂₀FN₅

950782-86-2

茚嗪氟草胺

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Brabham C, et al. Indaziflam herbicidal action: a potent cellulose biosynthesis inhibitor. Plant Physiol. 2014 Nov;166(3):1177-85.
   [Content Brief]

  [2]. Sebastian DJ, et al. Indaziflam: a new cellulose-biosynthesis-inhibiting herbicide provides long-term control of invasive winter annual grasses. Pest Manag Sci. 2017;73(10):2149-2162.  [Content Brief]

  [3]. Könen Adıgüzel S, et al. The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells. Hum Exp Toxicol. 2023;42:9603271231183145.  [Content Brief]