2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-18

Influenza A virus-IN-18 (Compound C2e) 是具有口服活性的 Influenza A virus 抑制剂 (IC50：对于 PR8/H1N1 为 2.5 μM； 对于 H3N2 为 6.42 μM)。Influenza A virus-IN-18 高亲和力直接结合 H1N1/PR8 HA 蛋白，其 KD 为 0.25 μM。Influenza A virus-IN-18 可用于甲型流感病毒感染的相关研究。

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Influenza A virus-IN-18

Influenza A virus-IN-18 Chemical Structure

CAS No. : 3085746-63-7

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Influenza A virus-IN-18 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Influenza A virus-IN-18 (Compound C2e) is an orally active inhibitor of Influenza A virus (IC50: 2.5 μM against PR8/H1N1; 6.42 μM against H3N2). Influenza A virus-IN-18 binds directly to the H1N1/PR8 HA protein with high affinity, with a KD of 0.25 μM. Influenza A virus-IN-18 is applicable to research related to Influenza A virus infection[1].

体外研究
(In Vitro)

Influenza A virus-IN-18 (1.25-20 μM) 可高亲和力直接结合 H1N1/PR8 HA 蛋白，其 KD 为 0.25 μM[1]。
Influenza A virus-IN-18 (48 h) 可强效抑制 MDCK 细胞中甲型流感病毒 PR8/H1N1 的复制，其 IC50 为 2.5 μM[1]。
Influenza A virus-IN-18 (48 h) 可抑制 MDCK 细胞中 H3N2 病毒的复制，其 IC50 为 6.42 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-18 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax T1/2 Bioavailability MRT
Mice[1] 2.0 mg/kg i.v. 3610 ng/mL / 1.09 h / 1.6 h
Mice[1] 10.0 mg/kg p.o. 2711 ng/mL 0.5 h 2.13 h 9.5 % /
体内研究
(In Vivo)

Influenza A virus-IN-18 (2.5-5 mg/kg/天；口服；一天一次) 在感染 H1N1 的 BALB/c 小鼠中实现了 50% 以上的存活率，与对照治疗相比具有更优的体重恢复效果[1]。
Influenza A virus-IN-18 (1000 mg/kg；口服；单次) 在 ICR 小鼠中耐受性良好，未观察到毒性或器官病变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

628.71

Formula

C35H40N4O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Influenza A virus-IN-18 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-183085746-63-7Influenza VirusMDCK cellsBALB/c miceinfluenza A virus hemagglutininHA-mediated membrane fusionH1N1 strainsviral entryH5N1 strainsVero cellsH5N1 pseudovirusH3N2 strainsInhibitorinhibitorinhibit

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