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  3. Inolitazone hydrochloride hydrate

Inolitazone hydrochloride hydrate  (Synonyms: Efatutazone hydrochloride hydrate; CS-7017 hydrochloride hydrate; RS5444 hydrochloride hydrate)

目录号: HY-14792C
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Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) 是新型 PPARγ 高亲和性激动剂,EC50Rosiglitazone (HY-17386) 的五十分之一,对于不表达 PPARγ 的 RIE 细胞无抑制性。Inolitazone hydrochloride hydrate 可用于癌症研究。

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CAS No. : 1048002-36-3

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Inolitazone hydrochloride hydrate 的其他形式现货产品:

Customer Review

Other Forms of Inolitazone hydrochloride hydrate:

    Inolitazone hydrochloride hydrate purchased from MCE. Usage Cited in: Cancer Med. 2018 May;7(5):1955-1966.  [Abstract]

    Protein expression in cells incubated with 40 μM Efatutazone for 12, 24, and 48 h.

    Inolitazone hydrochloride hydrate purchased from MCE. Usage Cited in: Exp Cell Res. 2017 Dec 15;361(2):246-256.  [Abstract]

    Western blot analysis for p21, p-p21, Cyclin D1. Bcl-2, Caspase 3, Cleaved Caspase 3, Caspase 9, Cleaved Caspase 9 and Bax in HCC827-GR and PC-9-GR cells treated with control, Efatutazone alone, Gefitinib alone, or Efatutazone combined with gefitinib for 48 h.

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    生物活性

    Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer[1][2].

    IC50 & Target[1]

    PPARγ

     

    分子量

    593.52

    Formula

    C27H30Cl2N4O5S

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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