2. Anti-infection
  3. Bacterial
  4. IP6C

IP6C 是一种特异性靶向 II 型 Thoeris 系统的抑制剂与噬菌体增敏剂。IP6C 通过竞争性结合 ThsB 催化口袋中的组氨酸，阻断 His-ADPR 警报信号的产生并抑制 ThsA 激活，从而解除细菌对噬菌体复制的停滞作用。IP6C 能选择性地使携带 II 型 Thoeris 系统的耐药菌 (如铜绿假单胞菌) 重新对噬菌体裂解敏感，且不影响其他细菌、对小鼠及人细胞系无毒。IP6C 能显著提高感染小鼠的存活率，可用于克服细菌噬菌体防御机制及研究铜绿假单胞菌感染。
Thoeris 系统：(名称源自埃及神话中的生育与保护女神)，是一种广泛分布于细菌和古菌中的抗噬菌体免疫防御系统。它属于细菌的“流产感染” (Abortion Infection, Abi) 机制：当单个细菌检测到噬菌体入侵时，会启动自杀程序死亡，从而阻断噬菌体的复制和扩散，保护周围的细菌群体免受感染。

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IP6C

IP6C Chemical Structure

CAS No. : 103313-38-8

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IP6C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IP6C is a specific inhibitor and phage sensitizer targeting type II Thoeris systems. IP6C competitively binds to histidine in the catalytic pocket of ThsB, blocks the production of the His-ADPR alarm signal and inhibits ThsA activation, thereby relieving bacterial stasis of phage replication. IP6C selectively resensitizes drug-resistant bacteria carrying type II Thoeris systems (such as Pseudomonas aeruginosa) to phage lysis, without affecting other bacteria, and shows no toxicity to mice and human cell lines. IP6C significantly improves the survival rate of infected mice, and can be used to overcome bacterial phage defense mechanisms and study Pseudomonas aeruginosa infections[1].
Thoeris system: (named after the Egyptian goddess of fertility and protection), is a widespread anti-phage immune defense system in bacteria and archaea. Thoeris system belongs to the "Abortion Infection (Abi)" mechanism of bacteria: when an individual bacterium detects phage invasion, it initiates a suicide program and dies, thereby blocking phage replication and spread, and protecting the surrounding bacterial population from infection.

体外研究
(In Vitro)

IP6C (0.1-1000 μM; 15 h) 可强效抑制枯草芽孢杆菌 (Bacillus subtilis) 中的 II 型 BaY2 Thoeris 抗噬菌体系统，介导 SPO1 噬菌体诱导的细菌裂解并恢复噬菌体的繁殖[1]。
IP6C (500 μM; 4 h, 80 min) 可通过阻断 BaY2ThsB 介导的 His-ADPR 警报信号生成，抑制枯草芽孢杆菌 (Bacillus subtilis) 中的 II 型 BaY2 Thoeris 系统，且不影响细胞内 NAD+ 水平[1]。
IP6C (1 mM; 15 h) 可抑制 Pseudomonas aeruginosa PAO1 中 II 型 MRSN11538 Thoeris 抗噬菌体系统，其 IC50 为 19 μM，从而介导 Lit1 噬菌体诱导的细菌裂解并恢复噬菌体的繁殖能力[1]。
IP6C (300 μM; 8.5 h, 24 h) 可在 polymicrobial 群落中选择性地使表达 II 型 MRSN11538 Thoeris 系统的 Pseudomonas aeruginosa PAO1 重新对 Lit1 噬菌体敏感，使 Pseudomonas aeruginosa 的滴度降低，且不会影响其他细菌物种，同时可在群落中保持 24 小时的稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IP6C 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Bacillus subtilis
Concentration: 0.1-1000 μM
Incubation Time: 15 h
Result: Mediated SPO1 phage-induced bacterial lysis and restoring phage reproduction, with an IC50 of 10 μM against type II BaY2 Thoeris anti-phage system in Bacillus subtilis.
体内研究
(In Vivo)

IP6C (50 mg/kg; i.p.; 单剂量) 与 Lit1 噬菌体联合给药可将铜绿假单胞菌感染的 BALB/c 小鼠的 7 天存活率提升至 86%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (7-week-old, female)[1]
Dosage: 50 mg/kg
Administration: i.p.; single dose
Result: Increased 7-day survival rate to 86% when combined with Lit1 phage.
Showed 0% 7-day survival rate when administered alone.
分子量

161.16

Formula

C8H7N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IP6C 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IP6C103313-38-8BacterialPseudomonas aeruginosa PAO1ThsASPO1 phagepseudomonas aeruginosaEnterococcus faecalis OG1RFThsBtype II Thoeris systemLit1 phageBALB/c miceBacillus subtilisInhibitorinhibitorinhibit

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