1. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  2. IPK Superfamily
  3. IP6K2-IN-1

IP6K2-IN-1 是一种选择性黄酮类化合物 IP6K2 抑制剂,其 IC50 值为 0.55 μM。IP6K2-IN-1 对 IP6K2 的抑制活性高于 IP6K1 和 IP6K3。IP6K2-IN-1 可作为先导化合物,用于进一步对 IP6K2 抑制剂进行结构修饰。

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IP6K2-IN-1

IP6K2-IN-1 Chemical Structure

CAS No. : 2926679-10-7

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IP6K2-IN-1 is a selective flavonoid-based IP6K2 inhibitor with an IC50 value of 0.55 μM[1]. IP6K2-IN-1 shows higher inhibitory potency against IP6K2 than IP6K1 and IP6K3. IP6K2-IN-1 can be utilised as a hit compound for further structural modifications of IP6K2 inhibitors[1].

IC50 & Target[1]

IP6K2

 

体外研究
(In Vitro)

IP6K2-IN-1 (Compound 20s)对 IP6K1 的 IC50 值为 2.87 µM,IP6K1/IP6K2 的 IC50 比值为 5.22 倍;对 IP6K3 的 IC50 值为 3.56 µM,IP6K3/IP6K2 的 IC50 比值为 6.47 倍[1]
IP6K2-IN-1 未能降低 HCT116 细胞中的 IP7 水平,表明其细胞渗透性较低[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

314.25

Formula

C16H10O7

CAS 号
性状

固体

颜色

brownish yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献
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产品名称:
IP6K2-IN-1
目录号:
HY-161032
需求量: