2. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase
  4. IPM-N001

IPM-N001 是一种碳酸酐酶 IX (CAIX) 配体，对 hCAIX 的 Kd 值为 <0.0337 nM。IPM-N001 被 68Ga 放射性偶联后可作为 CAIX 靶向放射性核素示踪剂。[68Ga]Ga-IPM-N001 表现出优异的肿瘤摄取率并且在使用 OS-RC-2 肿瘤小鼠的 PET/CT 成像研究中，显著提高肿瘤与背景的比率。IPM-N001 可用于透明细胞肾细胞癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

IPM-N001

IPM-N001 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

IPM-N001 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

查看所有亚型
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IPM-N001 is a carbonic anhydrase IX (CAIX) ligand with a Kd value of <0.0337 nM for hCAIX. When radio-conjugated with 68Ga, IPM-N001 serves as a CAIX-targeted radionuclide tracer. [68Ga]Ga-IPM-N001 exhibits excellent tumor uptake and significantly improves the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 can be used for the research of clear cell renal cell carcinoma[1].

IC50 & Target[1]

hCA IX

<0.0337 nM (Kd)

体外研究
(In Vitro)

IPM-N001 对纯化的 hCAIX 表现出高结合亲和力，其 Kd 值为 <0.0337 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IPM-N001 相关抗体:
体内研究
(In Vivo)

[68Ga]Ga-IPM-N001 (3.7-7.4 MBq；静脉注射；单次) 于雄性 Balb/c-nu 小鼠中实现了针对肾透明细胞癌 (ccRCC) 的高特异性肿瘤摄取，静态 PET/CT 检测值为 8.9 ± 1.1 %ID/g，ex vivo 生物分布检测值为 27.61 ± 7.48 %ID/g[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2258.51

Formula

C99H140N24O31S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IPM-N001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IPM-N001Radionuclide-Drug Conjugates (RDCs)Carbonic AnhydraseCarbonate dehydrataseOS-RC-2 cellshypoxiaclear cell renal cell carcinomahuman CAIXPET/CTFBScarbonic anhydrase IX (CAIX)PBSBalb/c-nu miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
IPM-N001
目录号：
HY-P11737
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z