2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis MDM-2/p53
  4. Ischemin

Ischemin 是一种 CBP 溴结构域抑制剂，能抑制 p53 与 CBP 的相互作用和细胞中的转录活性。Ischemin 能抑制 p53 诱导的 p21 激活，其 IC50 值为 5 µM。Ischemin 还能防止缺血心肌细胞凋亡 (apoptosis)。Ischemin 可用于心血管疾病 (如心肌缺血) 的研究。

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Ischemin

Ischemin Chemical Structure

CAS No. : 1357059-00-7

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5 mg ￥935
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10 mg ￥1488
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25 mg ￥2958
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Other Forms of Ischemin:

Ischemin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U2OS IC50
5 μM
Compound: 23
Inhibition of p53-CBP bromodomain interaction in human U2OS cells assessed as inhibition of p21 activation incubated overnight followed by doxorubicin addition measured after 24 hrs by luciferase reporter gene assay
Inhibition of p53-CBP bromodomain interaction in human U2OS cells assessed as inhibition of p21 activation incubated overnight followed by doxorubicin addition measured after 24 hrs by luciferase reporter gene assay
[PMID: 26701186]
U2OS IC50
5 μM
Compound: 5, MS210
Inhibition of p53-induced p21 expression in human U2OS cells by luciferase reporter gene assay
Inhibition of p53-induced p21 expression in human U2OS cells by luciferase reporter gene assay
10.1039/C1MD00201E
体外研究
(In Vitro)

Ischemin (50, 100 µM; 24 h) 抑制 U2OS 细胞中 DNA 损伤应激引起的 p53 激活[1]。
Ischemin (10 μM; 3 days) 通过抑制 caspase 3/7 的活性来阻断心肌细胞的凋亡[1]。
Ischemin 在 U2OS 细胞中抑制 p53 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ischemin 相关抗体:

Western Blot Analysis[1]

Cell Line: U2OS cells
Concentration: 50, 100 μM
Incubation Time: 24 h
Result: Inhibited the Doxorubicin-induced increased levels of p53 protein, its Ser15-phosphorylated (p53S15p) and Lys382-acetylated (p53K382ac).

Apoptosis Analysis[1]

Cell Line: U2OS cells
Concentration: 10 μM
Incubation Time: 3 days
Result: Functioned as a cellular protective agent againsted myocardial ischemic stress.
分子量

335.38

Formula

C15H17N3O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.80%

COA (285 KB)

产品使用指南 (1538 KB)
参考文献

Ischemin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ischemin1357059-00-7Epigenetic Reader DomainApoptosisMDM-2/p53U2OS293THEK293Tmyocardial ischemiap21apoptosiscardiomyocytesInhibitorinhibitorinhibit

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产品名称：
Ischemin
目录号：
HY-110315A
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