2. NF-κB Stem Cell/Wnt PI3K/Akt/mTOR Apoptosis Immunology/Inflammation
  3. Keap1-Nrf2 GSK-3 TNF Receptor Interleukin Related SOD
  4. Isoeucommin A

Isoeucommin A 是一种木脂素类化合物。Isoeucommin A 可激活 Nrf2/HO-1 通路，，诱导 GSK-3β 磷酸化。Isoeucommin A 可降低促炎细胞因子 TNF-α、IL-1β、IL-6 的水平，减少氧化应激标志物 MDA，增加抗氧化剂 SOD 和 GSH，减轻肾小球系膜细胞的氧化应激。Isoeucommin A 可在糖尿病肾病模型中减轻肾组织损伤、改善受损肾功能并提高肾小管上皮细胞活力。Isoeucommin A 可用于糖尿病肾病的研究。

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Isoeucommin A

Isoeucommin A Chemical Structure

CAS No. : 134859-90-8

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Isoeucommin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy[1].

体外研究
(In Vitro)

Isoeucommin A (31.25-125 μM; 24 h) 可激活正常人肾小球系膜细胞 (HRMCs) 中的 Nrf2/HO-1 通路[1]。
Isoeucommin A (61.3-125 μM; 24 h) 可通过提升 p-GSK-3β 水平激活高糖 (HG) 刺激的 HRMCs 中的 Nrf2/HO-1 通路[1]。
Isoeucommin A (31.25-125 μM; 24 h) 可增强高糖 (HG) 刺激的 HRMCs 的抗氧化能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isoeucommin A 相关抗体:

Western Blot Analysis[1]

Cell Line: normal human renal mesangial cells (HRMCs)
Concentration: 31.25 μM, 61.3 μM, 125 μM
Incubation Time: 24 h
Result: Significantly increased Nrf2 protein expression at 31.25 μM.
Significantly increased both Nrf2 and HO-1 protein expression at 61.3 μM and 125 μM, with the highest concentration (125 μM) producing the greatest increase in protein levels.

Western Blot Analysis[1]

Cell Line: high-glucose (HG)-stimulated human renal mesangial cells (HRMCs)
Concentration: 61.3 μM, 125 μM
Incubation Time: 24 h
Result: Significantly increased p-GSK-3β protein expression, the p-GSK-3β/GSK-3β ratio, Nrf2 protein expression, and HO-1 protein expression compared to the HG-only group, with 125 μM producing the most robust increases.
体内研究
(In Vivo)

Isoeucommin A (2.5-10 mg/kg；静脉注射；每日一次；持续 28 天) 可呈剂量依赖性激活 Nrf2/HO-1 通路，以改善 Streptozotocin (HY-13753) 诱导的糖尿病肾病大鼠的肾功能障碍、组织损伤、炎症及氧化应激[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 8 weeks old, STZ-induced diabetic nephropathy)[1]
Dosage: 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: i.v.; daily; 28 days
Result: Reduced blood glucose and increased body weight gain significantly in the high-dose group compared to the DN model group.
Reduced kidney index, serum blood urea nitrogen, serum and urine creatinine, and urinary albumin-to-creatinine ratio significantly in medium- and high-dose groups compared to the DN model group.
Reduced serum TNF-α, IL-1β, IL-6, and kidney tissue MDA levels significantly, and increased kidney tissue SOD and GSH levels significantly in all dose groups compared to the DN model group, with effects increasing in a dose-dependent manner.
Reduced inflammatory cell infiltration, glomerular enlargement, renal tubular dilation, and renal tubular epithelial cell vacuolation in a dose-dependent manner, with the high-dose group nearing normal tissue morphology.
Increased renal Nrf2 and HO-1 mRNA and protein expression in a dose-dependent manner, with statistically significant elevations compared to the DN model group.
分子量

550.55

Formula

C27H34O12
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isoeucommin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoeucommin A134859-90-8Keap1-Nrf2GSK-3TNF ReceptorInterleukin RelatedSODGlycogen synthase kinase-3Glycogen synthase kinase 3Tumor Necrosis Factor ReceptorTNFRILSuperoxide DismutaseHO-1IL-1βIL-6TNF-αGSHrenal mesangial cellsMDAGSK-3βNrf2lignan compoundSprague Dawley ratdiabetic nephropathyInhibitorinhibitorinhibit

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