2. Immunology/Inflammation
  3. COX Interleukin Related
  4. ISP-VT

ISP-VT (Isopropyl vanillate) 是一种 COX-2 抑制剂。ISP-VT 具有抗炎、解热和免疫调节的活性。ISP-VT 可减少中性粒细胞迁移与炎症因子释放。ISP-VT 可用于炎症免疫疾病等的研究。

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ISP-VT

ISP-VT Chemical Structure

CAS No. : 175796-45-9

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ISP-VT 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ISP-VT (Isopropyl vanillate) is a COX-2 inhibitor. ISP-VT exhibits anti-inflammatory, antipyretic and immunomodulatory activities. ISP-VT reduces neutrophil migration and the release of inflammatory factors. ISP-VT can be used for the research of inflammatory and immune diseases and other conditions[1][2].

IC50 & Target[2]

COX-2

 

IL-6

 

体外研究
(In Vitro)

ISP-VT (compound 4) (300 μM; 20 min) 可抑制 RBL-2H3 细胞中抗原诱导的脱颗粒作用，其 IC50 为 415 μ[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ISP-VT 相关抗体:
体内研究
(In Vivo)

ISP-VT (0.3-3 mg/kg；腹腔注射；单次给药) 可显著抑制 Carrageenan (HY-125474) 诱导的瑞士小鼠足肿胀[2]。
ISP-VT (1 mg/kg；腹腔注射；单次给药) 在瑞士小鼠体内通过选择性抑制 COX-2、减少中性粒细胞迁移与炎症因子释放，发挥抗炎与解热作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice treated carrageenan (adult, both sexes, 25-30 g)[2]
Dosage: 0.3 mg/kg; 1 mg/kg; 3 mg/kg
Administration: i.p.; single dose
Result: Reduced paw edema by 53.5% at the 3-hour peak (1 mg/kg dose).
Reduced paw edema by 59.8% at the 3-hour peak (3 mg/kg dose).
Did not significantly reduce edema (0.3 mg/kg dose).
Animal Model: Swiss mice (both sexes, 25-30 g) with carrageenan-induced paw edema, carrageenan-induced peritonitis, and Brewer’s yeast-induced hyperthermia[2]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced paw edema induced by carrageenan, dextran sulfate, compound 48/80, histamine, serotonin, bradykinin, and PGE2.
Decreased leukocyte and neutrophil recruitment, rolling, adhesion, and myeloperoxidase (MPO) activity.
Lowered TNF-α and IL-6 levels and vascular permeability, and downregulated COX-2 expression and selectively inhibited COX-2 activity.
Alleviated gastric toxicity compared with Indomethacin (HY-14397) and reduced rectal temperature in yeast-induced hyperthermic mice.
分子量

210.23

Formula

C11H14O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ISP-VT 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISP-VT175796-45-9Isopropyl vanillateCOXInterleukin RelatedCyclooxygenaseILimmediate hypersensitivity (type i) allergyCOX-2RBL-2H3 cellstumor necrosis factor-αinterleukin-6Swiss micemyeloperoxidaseneutrophilmouse subplantar tissuecyclooxygenase-2Inhibitorinhibitorinhibit

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