2. MAPK/ERK Pathway Cytoskeleton Metabolic Enzyme/Protease
  3. JNK Cadherin Collagen PAI-1
  4. JNK3-IN-11

JNK3-IN-11 是一种选择性 JNK3 抑制剂，其 IC50 为 2.08 nM。JNK3-IN-11 可结合至 JNK3 的 ATP 结合口袋，与 Met149 形成保守氢键，并通过水分子介导与 Lys93 形成氢键。JNK3-IN-11 可抑制 TGF-β1 诱导的 c-Jun 磷酸化，降低促纤维化标志物 COL1A1 和 PAI-1 的水平，恢复 E-cadherin 的表达，且对足细胞损伤具有保护作用。JNK3-IN-11 可用于慢性肾脏病的研究。

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JNK3-IN-11

JNK3-IN-11 Chemical Structure

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JNK3-IN-11 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease[1].

IC50 & Target[1]

Collagen I

 

JNK3

2.08 nM (IC50)

体外研究
(In Vitro)

JNK3-IN-11 (Compound 50b) (40 min) 可强效抑制重组人 JNK3，其 IC50 为 2.08 nM,且相对于 JNK1、JNK2、p38α、DYRK1B 和 RIPK3 表现出显著的选择性[1]。
JNK3-IN-11 (5 μM; 24 h) 可有效抑制 TGF-β1 诱导的 c-Jun 磷酸化，降低促纤维化标志物 (COL1A1、PAI-1) 的表达水平，恢复 E-钙粘蛋白水平，且在人足细胞中无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3-IN-11 相关抗体:

Western Blot Analysis[1]

Cell Line: Podocytes
Concentration: 5 μM
Incubation Time: 24 h
Result: Reduced TGF-β1-induced COL1A1, PAI-1 expression.
Increased reduced E-cadherin levels.
分子量

438.88

Formula

C23H20ClFN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK3-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3-IN-11JNKCadherinCollagenPAI-1c-Jun N-terminal kinasePlasminogen activator inhibitor-1Lys93COL1A1p38αMet149c-JunTGF-β1JNK1JNK3JNK2Inhibitorinhibitorinhibit

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