2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) COX NO Synthase
  4. JNUTS013

JNUTS013 是一种 NLRP3 炎性小体抑制剂。JNUTS013 促进 NLRP3 的蛋白酶体依赖性降解，并抑制下游细胞因子的释放。JNUTS013 可下调包括 iNOS 和 COX-2 在内的炎症相关蛋白的表达。JNUTS013 具有抗炎作用，可用于炎症性疾病的研究。

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JNUTS013

JNUTS013 Chemical Structure

CAS No. : 2763983-45-3

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JNUTS013 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNUTS013 is a NLRP3 inflammasome inhibitor. JNUTS013 promotes proteasome-dependent degradation of NLRP3 and inhibits the release of downstream cytokines. JNUTS013 downregulates the expression of inflammation-related proteins including iNOS and COX-2. JNUTS013 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases[1].

IC50 & Target[1]

COX-2

 

NLRP3 inflammasome

 

体外研究
(In Vitro)

JNUTS013 (10 μM; 24 h) 可抑制 LPS (HY-D1056) 诱导的 RAW264.7 巨噬细胞中 NO 的生成，且在此条件下细胞仍保持较高存活率[1]。
JNUTS013 (10 μM; 24 h) 可抑制 RAW264.7 巨噬细胞中 LPS 诱导的 iNOS、COX-2 和 NLRP3 蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNUTS013 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 macrophages treated LPS
Concentration: 10 μM
Incubation Time: 24 h
Result: Downregulated the expression of LPS-induced iNOS, COX-2, and NLRP3 proteins in RAW264.7 macrophages.
分子量

358.39

Formula

C20H22O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNUTS013 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNUTS0132763983-45-3JNUTS 013JNUTS-013NOD-like Receptor (NLR)COXNO SynthaseCyclooxygenaseNitric oxide synthasesNOSmacrophageslipopolysaccharidenitric oxideNLRP3COX-2iNOSRAW264.7 macrophagesNLRP3 inflammasomecytokineproteasomeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-182779
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