2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis Bcl-2 Family Survivin
  4. JS04

JS04 是一种 EGFRL858R/T790M 激酶抑制剂。JS04 可激活内源性和外源性凋亡 (apoptosis) 通路，诱导细胞周期 G2/M 期阻滞。JS04 可用于耐药性非小细胞肺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

JS04

JS04 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

JS04 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JS04 is a EGFRL858R/T790M kinase inhibitor. JS04 activates both endogenous and exogenous apoptosis (apoptosis) pathways and induces G2/M phase arrest of the cell cycle. JS04 is applicable to the research of drug-resistant non-small cell lung cancer[1].

IC50 & Target[1]

EGFRL858R/T790M

 

Bcl-2

 

Bcl-xL

 

体外研究
(In Vitro)

JS04 (72 h) 可强效抑制 H1975 和 A549 非小细胞肺癌 (NSCLC) 细胞的增殖，其 IC50 值分别为 8.11 μM 和 11.58 μM；同时该化合物针对人 Hs27 成纤维细胞具有良好的安全窗，选择性指数为 2.52[1]。
JS04 (10-20 μM; 48 h) 可在 H1975 细胞中诱导剂量依赖性凋亡[1]。
JS04 (10-20 μM; 48 h) 可在 H1975 细胞中诱导 G2/M 期细胞周期阻滞[1]。
JS04 (72 h) 可同时激活内源性凋亡通路 (下调 BCL-2、BCL-xL、Survivin 表达) 与外源性凋亡通路 (上调 TRAIL R2/DR5 表达)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JS04 相关抗体:

Apoptosis Analysis[1]

Cell Line: H1975 NSCLC
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: At 20 μM, induced 74% total apoptotic cell death.
At 10 μM, produced a lower level of apoptosis compared to 20 μM, as confirmed by reduced viable cell populations.

Cell Cycle Analysis[1]

Cell Line: H1975 NSCLC
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: At 20 μM, caused an approximately 3 to 4-fold increase in the G2/M cell population (35% of cells in G2/M phase), with a concomitant decrease in G0/G1 phase cells.
体内研究
(In Vivo)

JS04 (6.25-100 μM；浸泡处理；持续给药；从 5.5 至 6 小时胚龄到 96 小时胚龄) 在斑马鱼 (Danio rerio) 胚胎中显示出良好的急性安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AB-WT (fertilised embryos)[1]
Dosage: 6.25 μM; 12.5 μM; 25 μM; 50 μM; 100 μM
Administration: immersion; continuous; 5.5-6 hpf through 96 hpf
Result: Caused 100% embryo mortality at 100 μM and 96 hpf.
Resulted in < 20% mortality across all time points at 6.25, 12.5, and 25 μM.
分子量

382.89

Formula

C20H23ClN6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JS04 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JS04JS 04JS-04EGFRApoptosisBcl-2 FamilySurvivinEpidermal growth factor receptorErbB-1HER1MET793G2/M phase cell cycle arrestA549 NSCLC cellszebrafish embryosEGFRL858R/T790M kinasenon-small-cell lung cancer cellsH1975 NSCLC cellsGLN791extrinsic apoptotic pathwaysintrinsic apoptotic pathwaysInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
JS04
目录号：
HY-182031
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z