2. Immunology/Inflammation
  3. MHC
  4. KDEL

KDEL 是一种四肽，是内质网回收/滞留信号。KDEL 可将外源性抗原肽靶向递送至内质网，显著增强并延长 MHC I 类分子呈递，有效提升抗肿瘤免疫应答。

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Custom Peptide Synthesis

KDEL

KDEL Chemical Structure

CAS No. : 113516-56-6

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KDEL 相关抗体

Top Publications Citing Use of Products

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MHC I MHC II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses[1].

体外研究
(In Vitro)

KDEL (10 μM; 30 min-10 h) 与 OVA257-264 的 C 端融合后，可增强 EL-4 和 RMA 细胞上 MHC I 类相关的肽段呈递[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KDEL 相关抗体:
体内研究
(In Vivo)

KDEL (10 μM; DC 负载后皮下注射；2 次) 在C57BL/6 小鼠中显著增强并延长外源性肽的 MHC I 类分子呈递，诱导更强特异性 CTL 应答并显著抑制 E.G7‑OVA 肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (6-8 weeks old) with E.G7‑OVA tumor challenge[1]
Dosage: 10 μM OVA257‑264‑KDEL peptide
Administration: subcutaneous injection ( days 0 and 7)
Result: Induced greatly enhanced specific CD8+ cytotoxic T lymphocyte (CTL) responses, remarkably prolonged surface MHC class I/peptide complex display, and resulted in significant inhibition of E.G7‑OVA tumor growth in vivo compared with OVA257‑264 or OVA257‑264‑TEWT peptide groups.
分子量

503.55

Formula

C21H37N5O9
CAS 号
Sequence

Lys-Asp-Glu-Leu
Sequence Shortening

KDEL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KDEL 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDEL113516-56-6MHCMajor Histocompatibility Complexdendritic cellsERMHC class IproteasomeGolgiEL-4 cellsKDEL receptorTAPantigen-presenting cellsbrefeldin AInhibitorinhibitorinhibit

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目录号：
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