2. GPCR/G Protein
  3. Adenosine Receptor
  4. KF20274

KF20274 是一种具有口服活性的腺苷 A1 受体 (adenosine A1 receptor) 拮抗剂。KF20274 可增加大鼠的粪粒排出量，且在促排便剂量下不影响小肠推进运动或胃排空。KF20274 在促排便剂量下不会诱发腹泻。KF20274 可用于便秘的研究。

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KF20274

KF20274 Chemical Structure

CAS No. : 143394-68-7

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KF20274 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KF20274 is an orally active adenosine A1 receptor antagonist. KF20274 increases the fecal pellet output in rats, and does not affect small intestinal propulsion or gastric emptying at defecation-increasing doses. KF20274 does not induce diarrhea at defecation-increasing doses. KF20274 can be used for the research of constipation[1].

IC50 & Target[1]

A1AR

 

体内研究
(In Vivo)

KF20274 (0.0003-0.03 mg/kg; 口服) 以剂量依赖方式增加健康大鼠的粪便排出量；在 0.01 和 0.03 mg/kg 剂量下，大鼠粪便湿重和干重均出现显著增加[1]。
KF20274 (0.01-3 mg/kg; 口服) 不会改变大鼠的小肠推进功能及胃排空情况[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 150-250 g)[1]
Dosage: 0.0003, 0.001, 0.003, 0.01, 0.03 mg/kg
Administration: p.o.
Result: Increased fecal wet weight and dry weight.
Maintained fecal water content at 51-55%.
Resulted in 0/10 incidence of diarrhea across all tested doses.
分子量

367.49

Formula

C21H29N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KF20274 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KF20274143394-68-7KF 20274KF-20274Adenosine ReceptorP1 receptoradenosine A1 receptorgastrointestinal propulsionlower gastrointestinal propulsionfecal pellet outputgastric emptyinghealthy ratsdiarrheafecal outputconstipationsmall intestinal propulsionInhibitorinhibitorinhibit

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产品名称：
KF20274
目录号：
HY-182340
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