2. Cell Cycle/DNA Damage
  3. Folate Receptor (FR)
  4. KHK2805

KHK2805 (RA15-7) 是一种抗叶酸受体 α (FOLR1) 人源化抗体，对人源 FOLR1 的 Kd 为 0.647 nM。KHK2805 可结合 FOLR1 的独特表位，介导针对表达 FOLR1 细胞的抗体依赖的细胞介导的细胞毒性作用和补体依赖的细胞毒性作用。KHK2805 对卵巢癌细胞及 Platinum (HY-W096169D) 耐药卵巢癌细胞均具有细胞毒性。KHK2805 可用于卵巢癌等肿瘤的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KHK2805

KHK2805 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

KHK2805 相关抗体

Top Publications Citing Use of Products

查看 Folate Receptor (FR) 亚型特异性产品:

查看所有亚型
FR-α

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer[1].

反应种属

Human
体外研究
(In Vitro)

KHK2805 (10 μg/mL; 1 h) 可与表达 FOLR1 的人卵巢癌细胞系 IGROV1、OVMANA、SKOV3 及 OVCAR3 强结合[1]。
KHK2805 (0.1-10000 ng/mL; 2 h) 可诱导针对表达 FOLR1 的人卵巢癌细胞系 IGROV1 和 OVMANA 的补体依赖性细胞毒性 (CDC)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KHK2805 相关抗体:
体内研究
(In Vivo)

KHK2805 (0.1-10 mg/kg; i.v.; twice/once a week) 可显著降低 Platinum (HY-W096169D) 耐药性卵巢癌腹膜播散 SCID 小鼠的腹腔肿瘤负荷与腹水量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (C.B-17/Icr-scid/scid Jcl, female, 6 weeks old, Platinum (HY-W096169D)-resistant peritoneal dissemination and malignant ascites model induced by intraperitoneal inoculation of IGROV1 cells)[1]
Dosage: 0.1 mg/kg; 1 mg/kg; 10 mg/kg
Administration: i.v.; twice a week; once a week
Result: Significantly reduced intraperitoneal tumor burden and eliminated detectable malignant ascites (10 mg/kg, twice a week).
Significantly reduced both intraperitoneal tumor burden and ascites volume (1 mg/kg, once a week).
Reduced tumor burden and ascites volume, with no statistically significant effects (0.1 mg/kg, once a week).
Significantly prolonged median survival.
基因 ID

2348  [NCBI]

Accession
靶点

FOLR1/FRA
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KHK2805 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHK2805RA15-7, HuRA15-7AccKHK 2805KHK-2805Folate Receptor (FR)FOLR3CDCADCCovarian cancer cellsSKOV3SCID miceplatinum-resistant ovarian cancer cellsFOLR1IGROV1FOLR2Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KHK2805
目录号：
HY-P992004
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z