Komaroidine 

Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight^[1][2].

Komaroidine (compound B2) 可强效抑制Xoo、Xac 和 Psa，其对应的 EC₅₀ 值分别为 1.12 μg/mL、4.85 μg/mL 和 20.08 μg/mL^[1]。
Komaroidine (12.5-50.0 μg/mL；作用 15 h) 可在 Xoo 细胞中诱导呈剂量依赖性的 ROS 积累，在 50.0 μg/mL 浓度下积累量可提升 4.1 倍^[1]。
Komaroidine (3.125-50.0 μg/mL) 可破坏 Xoo 细胞中的抗氧化酶活性，在浓度 ≥12.5 μg/mL 时可使 SOD 完全失活并导致 CAT 活性下降^[1]。
Komaroidine (25.0 μg/mL) 可协同增强 Xoo 对 0.05 mM H₂O₂ 的敏感性，完全抑制细菌生长^[1]。
Komaroidine (12.5-50.0 μg/mL；作用 15 h) 可在 Xoo 细胞中诱导剂量依赖性凋亡，在 50.0 μg/mL 浓度下总凋亡率达 56.90%，并可呈剂量依赖性地提高 Xoo 细胞的膜通透性^[1]。
Komaroidine (compound B2) (25.0 μg/mL；15 h) 可改变 Xoo PXO99A 细胞的转录组，影响代谢、应激及细胞凋亡相关通路^[1]。
Komaroidine (compound B2) (200 μg/mL；盆栽试验施用) 对水稻白叶枯病 (BLB) 表现出优异的防治效果，可显著降低受感染组织中的细菌载量^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

214.31

C₁₄H₁₈N₂

6649-76-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu HW, et al. Natural product scaffold-based bactericide discovery: novel β-carboline derivatives as potent reactive oxygen species inducers for crop disease control. Pest Manag Sci. Published online January 10, 2026.  [Content Brief]

  [2]. Tulyaganov, et al. Alkaloids from plants of the genus Nitraria. Chem Nat Compd 42, 198-200 (2006).