2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease
  3. Microtubule/Tubulin Cytochrome P450
  4. KOSN 1724

KOSN 1724 是一种抗癌剂。KOSN 1724 可破坏微管蛋白 (tubulin) 活性、稳定微管 (microtubules) 并抑制癌细胞增殖。KOSN 1724 可抑制细胞色素 P450 (cytochrome P450) 3A4、CYP2C9 和 CYP2C19 的活性。KOSN 1724 可用于癌症研究。

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KOSN 1724

KOSN 1724 Chemical Structure

CAS No. : 693272-98-9

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KOSN 1724 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KOSN 1724 is an anticancer agent. KOSN 1724 disrupts tubulin activity, stabilizes microtubules, and inhibits cancer cells proliferation. KOSN 1724 inhibits cytochrome P450 3A4, CYP2C9, and CYP2C19 activity. KOSN 1724 can be used for the research of cancer[1].

IC50 & Target[1]

CYP3A4

7.1 μM (IC50)

CYP2C19

10.9 μM (IC50)

CYP2C9

12.9 μM (IC50)

体外研究
(In Vitro)

KOSN 1724 可强效抑制 MCF-7、NCI/ADR、A549 及 Skov 癌细胞系的增殖，其 IC50 值为 2.5、6.1、5.3 和 5.3 nM[1]。
KOSN 1724 可抑制 CYP3A4、CYP2C9 和 CYP2C19 的酶活性，其 IC50 值分别为 7.1 μM、12.9 μM 和 10.9 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KOSN 1724 相关抗体:
分子量

473.60

Formula

C27H39NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KOSN 1724 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KOSN 1724693272-98-9KOSN1724KOSN-1724Microtubule/TubulinCytochrome P450CYPsNCI/ADRcytochrome P450tubulinA549CYP3A4CYP2C9cancer cellsMCF-7microtubuleCYP2C19Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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