2. Cell Cycle/DNA Damage MAPK/ERK Pathway GPCR/G Protein
  3. PERK Ras
  4. KRAS-IN-54

KRAS-IN-54 是一种大环类 KRAS 抑制剂。KRAS-IN-54 对 KRASG12D 和 KRASG13D 突变的细胞活力和 pERK 抑制均展现出活性。KRAS-IN-54 可用于 KRAS 突变型癌症的研究，包括胰腺腺癌、结直肠癌、非小细胞肺癌、食管癌、胆囊癌、黑色素瘤、卵巢癌和子宫内膜癌。

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KRAS-IN-54

KRAS-IN-54 Chemical Structure

CAS No. : 3084918-70-4

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KRAS-IN-54 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer[1].

IC50 & Target[1]

KRas G12D

 

KRAS G13D

 

体外研究
(In Vitro)

KRAS-IN-54 (compound 3) 可抑制 AGS (KRASG12D) 细胞的活力，其 IC50 为 10 nM；同时可抑制 HCT-116 (KRASG13D) 细胞的活力，IC50 为 27 nM[1]。
KRAS-IN-54 可抑制 AGS (KRASG12D) 细胞中 ERK 的磷酸化，其 IC50 为 9 nM；同时可抑制 HCT-116 (KRASG13D) 细胞中 ERK 的磷酸化，IC50 为 10 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS-IN-54 相关抗体:
分子量

1192.39

Formula

C60H78F5N11O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS-IN-54 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS-IN-543084918-70-4PERKRasProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseKRAS G13Dpancreatic adenocarcinomaovarian cancerKRAS G12Dcolorectal cancerendometrial cancergallbladder canceresophageal cancernon-small cell lung cancermelanomaInhibitorinhibitorinhibit

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目录号：
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