2. GPCR/G Protein MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. Ras PERK
  4. KRAS-IN-56

KRAS-IN-56 (Compound 18) 是一种 KRAS 抑制剂，EC50 为 33 μM。KRAS-IN-56 抑制 GTP-KRAS 与 SOS1 之间的相互作用。KRAS-IN-56 可诱导 p-ERK 水平降低。KRAS-IN-56 可用于肺癌的相关研究。

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KRAS-IN-56

KRAS-IN-56 Chemical Structure

CAS No. : 2375482-34-9

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KRAS-IN-56 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer[1].

IC50 & Target[1]

K-RAS

33 μM (EC50)

体外研究
(In Vitro)

KRAS-IN-56 可与纯化的 GCP-KRASG12D 蛋白结合，通过 ITC 测得其 Kd 为 20 μM[1]。
KRAS-IN-56 在一项生化分析实验中可抑制 GTP-KRAS 与 SOS1 之间的相互作用，其 EC50 为 33 μM[1]。
KRAS-IN-56 (10-8-10-4 M; 2 h) 可在 NCI-H358 KRASG12C 突变型肺癌细胞中诱导 pERK 水平呈剂量依赖性降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS-IN-56 相关抗体:
分子量

321.37

Formula

C19H19N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS-IN-56 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS-IN-562375482-34-9RasPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseHRASGCP-KRASG12DKRASlung cancerGDP-KRASNRASERKGTP-KRASNCI-H358 KRASG12C mutant lung cancer cellsSOS1Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-182411
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