2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. Kuanoniamine A

Kuanoniamine A 是一种吡啶并吖啶类生物碱，也是一种抗癌剂。Kuanoniamine A 可抑制 DNA 合成，诱导细胞凋亡 (apoptosis)，并通过减少 G2/M 期细胞比例调控细胞周期。Kuanoniamine A 可抑制人类淋巴细胞增殖。Kuanoniamine A 可用于乳腺癌、神经胶质瘤、非小细胞肺癌、黑色素瘤的相关研究。

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Kuanoniamine A

Kuanoniamine A Chemical Structure

CAS No. : 133401-10-2

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Kuanoniamine A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kuanoniamine A is a pyridoacridine alkaloid and also an anticancer agent. Kuanoniamine A inhibits DNA synthesis, induces apoptosis, and regulates the cell cycle by reducing the proportion of cells in the G2/M phase. Kuanoniamine A inhibits the proliferation of human lymphocytes. Kuanoniamine A can be used in research related to breast cancer, glioma, non-small cell lung cancer, and melanoma[1].

体外研究
(In Vitro)

Kuanoniamine A (48 h) 可强效抑制 MCF-7、MDA-MB-231、NCI-H460、SF-268、UACC-62 及 MRC-5 细胞的生长，在持续暴露 48 h 后其 GI50 值为 0.12 至 4.67 μM[1]。
Kuanoniamine A (0.04-86.51 μM; 6, 12, 24, 48 h) 可强效抑制 MCF-7 细胞中的 DNA 合成，具有浓度依赖性效应[1]。
Kuanoniamine A (0.04-86.51 μM; 6-48 h) 以时间依赖的方式降低 MCF-7 细胞活力：在暴露 6 h 后，0.04 μM 浓度下细胞活力降至 70%，24 h 和 48 h 后细胞活力下降程度更为显著[1]。
Kuanoniamine A (0.04-86.51 μM; 6-48 h) 以时间依赖方式降低 MCF-7 细胞的细胞内蛋白质含量，其作用趋势与通过 MTT 法检测的细胞活力变化一致[1]。
Kuanoniamine A (0.34 μM; 24 h) 可降低 MCF-7 细胞处于 G2/M 期的比例，使细胞在 G1 期累积，并相对于未处理的对照细胞降低 S 期细胞比例[1]。
Kuanoniamine A (0.5-1.0 μM; 24 h) 相对于未处理的对照细胞可增加凋亡 MCF-7 细胞的数量[1]。
Kuanoniamine A (0.5-2.5 μM; 24 h) 可在作用 24 h 后，于 0.5 μM 和 1.0 μM 浓度下将 MCF-7 细胞活力维持在 ≥ 70%，而 2.5 μM 浓度则会使细胞活力急剧降至 35.7%[1]。
Kuanoniamine A (0.12-86.51 μM; 96 h) 可强效抑制 PHA 诱导的人淋巴细胞增殖，持续暴露 96 h 后的 IC50 为 1.50 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kuanoniamine A 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MCF-7
Concentration: 0.34 μM
Incubation Time: 24 h
Result: Caused an extensive reduction in the fraction of cells in G2/M phase (5.71% vs.
12.17% in control), a corresponding accumulation of cells in G1 phase (81.41% vs.
70.04% in control), and a reduction in the S phase fraction (12.88% vs.
17.79% in control).

Apoptosis Analysis[1]

Cell Line: MCF-7
Concentration: 0.5 and 1.0 μM
Incubation Time: 24 h
Result: Increased the number of apoptotic cells; 0.5 μM treatment resulted in 6.19% apoptotic cells, and 1.0 μM treatment resulted in 7.2% apoptotic cells, compared to 1.41% in untreated control cells.

Cell Viability Assay[1]

Cell Line: MCF-7
Concentration: 0.5, 1 and 2.5 μM
Incubation Time: 24 h
Result: Moderately reduced viability at 0.5 and 1.0 μM (≥70% viable cells), while 2.5 μM caused a drastic decrease in viability to 35.7%.
分子量

289.31

Formula

C16H7N3OS
CAS 号
结构分类
初始来源

Oceanapia sagittaria
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kuanoniamine A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuanoniamine A133401-10-2DNA/RNA SynthesisApoptosiscell cycleOceanapia sagittarianon small cell lung cancergliomabreast carcinomahuman non-tumour cell linesapoptosisDNA synthesishuman tumour cell lineshuman lymphocytesInhibitorinhibitorinhibit

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