2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. KW-2581

KW-2581 是一种甾体选择性甾体硫酸酯酶 (STS) 抑制剂，其 IC50 为 4 nM。KW-2581 以 13 nM 的 IC50 值抑制 ZR-75-1 细胞的 STS 活性。KW-2581 以 0.18 nM 的 IC50 值抑制 E1S 诱导的 ZR-75-1 细胞生长。KW-2581 在体外和体内均可抑制硫酸酯化雌激素依赖性乳腺癌细胞的生长。KW-2581 可诱导 E1S 诱导的肿瘤消退。KW-2581 可用于激素受体阳性乳腺癌的研究。

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KW-2581

KW-2581 Chemical Structure

CAS No. : 284045-56-3

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KW-2581 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
4 nM
Compound: 5, KW-2581
Inhibition of recombinant human STS transfected in CHO cells using MUS as substrate after 30 mins by fluorescence assay
Inhibition of recombinant human STS transfected in CHO cells using MUS as substrate after 30 mins by fluorescence assay
[PMID: 26163883]
分子量

460.63

Formula

C25H36N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KW-2581 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KW-2581284045-56-3KW2581KW 2581Steroid SulfataseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-123868
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