2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. KY0418

KY0418 是一种选择性 GPX4 抑制剂。KY0418 可选择性地共价修饰 GPX4 的硒代半胱氨酸残基并抑制 GPX4 的活性。KY0418 可诱导铁死亡 (ferroptosis) 并抑制细胞增殖。KY0418 可用于铁死亡和癌症相关研究。

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KY0418

KY0418 Chemical Structure

CAS No. : 3024369-07-8

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KY0418 相关抗体

Top Publications Citing Use of Products

查看 Glutathione Peroxidase 亚型特异性产品:

查看所有亚型
GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer[1].

IC50 & Target[1]

GPX4

 

体外研究
(In Vitro)

KY0418 (E46) 可强效抑制 786-O 细胞增殖，其 IC50 ≤ 100 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KY0418 相关抗体:
分子量

588.62

Formula

C28H35F3N8O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KY0418 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY04183024369-07-8KY 0418KY-0418Glutathione PeroxidaseFerroptosis786-O cellsferroptosiscancercancer cell proliferationInhibitorinhibitorinhibit

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目录号：
HY-186143
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