2. Metabolic Enzyme/Protease Anti-infection
  3. Elastase Bacterial
  4. LasB-IN-3

LasB-IN-3 是铜绿假单胞菌 (Pseudomonas aeruginosa) 的弹性蛋白酶 (LasB) 抑制剂，其 IC50 值为 8.5 nM。LasB-IN-3 对 Met128Val 突变体的 IC50 为 58.9 nM。LasB-IN-3 可结合野生型及 Met128Val 突变体 LasB 的活性位点，螯合锌离子，形成氢键与 CH-π 相互作用，从而抑制 LasB 的蛋白水解活性。LasB-IN-3 可提高 LasB 诱导的急性肺损伤小鼠模型的存活率。LasB-IN-3 可用于铜绿假单胞菌 (Pseudomonas aeruginosa) 感染的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

LasB-IN-3

LasB-IN-3 Chemical Structure

CAS No. : 2762675-42-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

LasB-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LasB-IN-3 is a protease elastase (LasB) inhibitor of Pseudomonas aeruginosa with an IC50 value of 8.5 nM. LasB-IN-3 shows an IC50 of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models. LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection[1].

体外研究
(In Vitro)

LasB-IN-3 (Compound 21) 可强效抑制野生型铜绿假单胞菌 LasB，其 IC50 为 8.5 ± 0.5 nM；其对 Met128Val 突变体的活性降低了约 7 倍 (IC50 = 58.9 nM)[1]。
LasB-IN-3 可在猪肺表面活性物质存在的情况下抑制铜绿假单胞菌 LasB，其 IC50 为 45 nM，活性降低的原因是其与表面活性蛋白的结合率达 37.2 ± 0.8%[1]。
LasB-IN-3 (0-100 μM) 对人源 A549、HepG2 和 HEK293 细胞系仅表现出极低的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LasB-IN-3 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 C0 AUC0-t MRT Vz CL_obs
Mice[1] 2 mg/kg i.v. 2.30 ± 0.4 h 8.55 ± 6.96 μg/mL 4.68 ± 1.18 μg/mL·h 2.8 ± 0.6 h 1.19 ± 0.4 L/kg 5.89 ± 1.2 mL/min/kg
体内研究
(In Vivo)

LasB-IN-3 (Compound 21) (300 μM；鼻内滴注) 可使经 LasB 诱导的急性肺损伤攻毒的 C57BL/6 小鼠的存活率达到 100%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (8-week-old male; acute lung injury model via intranasal instillation of 40 μg purified Pseudomonas aeruginosa LasB elastase)[1]
Dosage: 300 μM
Administration: intranasal; single dose (preincubated with LasB prior to instillation)
Result: Achieved 100% survival over 7 days.
分子量

381.79

Formula

C18H21ClNO4P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LasB-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LasB-IN-32762675-42-1ElastaseBacterialCalu-3 cellsMet128Val mutant LasBclinical isolatesLasBPseudomonas aeruginosa PA14Pseudomonas aeruginosahuman metalloproteasesTACEpulmonary surfactant proteinsCOX-1Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
LasB-IN-3
目录号：
HY-181647
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z