2. Others
  3. Fluorescent Dye
  4. LCP

LCP 是一种可用于亚细胞定位的荧光探针。LCP 可通过荧光共振能量转移响应细胞微环境的极性变化，在低极性环境中发射蓝色荧光，在高极性环境中发射红色荧光。LCP 可实现药物诱导细胞凋亡过程中溶酶体与细胞质膜动态变化的双色可视化，并通过定位和发射颜色变化监测细胞活力。LCP 可用于癌症研究。

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LCP

LCP Chemical Structure

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LCP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LCP is a fluorescent probe applicable for subcellular localization. LCP responds to polarity changes in the cellular microenvironment via fluorescence resonance energy transfer, emitting blue fluorescence in low-polarity environments and red fluorescence in high-polarity environments. LCP enables dual-color visualization of dynamic changes in lysosomes and cytoplasmic membranes during drug-induced cell apoptosis, and monitors cell viability through localization and emission color changes. LCP can be used in cancer research[1].

体外研究
(In Vitro)

荧光探针 LCP (10 μM) 在无细胞溶剂体系中表现出极性依赖的荧光发射位移，其特征吸收峰和荧光峰可响应溶剂极性的变化[1]。
荧光探针 LCP (10 μM) 可在无细胞 GUV 膜模型中区分脂质相：在 Ld (高极性) 相中发射红色荧光，在 Lo (低极性) 相中发射蓝色荧光[1]。
荧光探针 LCP (0-40 μM) 对 HeLa 细胞的细胞毒性低，在最高 40 μM 的浓度下仍可用于活细胞成像应用[1]。
荧光探针 LCP (10 μM; 15 min) 可定位至活 HeLa 细胞的溶酶体中 (与 LysoTracker Red 的共定位系数为 0.91)，并可定位至顺铂诱导的凋亡 HeLa 细胞的质膜上 (与 DiO 的共定位系数为 0.83 和 0.88)[1]。
荧光探针 LCP (10 μM; 10 min) 在顺铂诱导的凋亡 HeLa 细胞中会以浓度依赖的方式发生荧光从蓝色 (溶酶体定位) 到红色 (细胞膜定位) 的转变，且随着顺铂浓度升高，蓝色荧光逐渐减弱、红色荧光逐渐增强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LCP 相关抗体:

Immunofluorescence[1]

Cell Line: HeLa cells (cisplatin-induced apoptosis, time-dependent)
Concentration: 10 μM (LCP); 30 μM (cisplatin pre-treatment)
Incubation Time: 10 min (LCP incubation); 0-24 h (cisplatin pre-treatment)
Result: Emitted only blue fluorescence (lysosomal localization) in HeLa cells pre-treated with 30 μM cisplatin for 0 h (live cells).
Showed gradually decreased blue channel fluorescence (lysosomal) and increasingly prominent red channel fluorescence (plasma membrane localization) in cells pre-treated for 6, 12, 18, or 24 h.
分子量

975.09

Formula

C56H71IN4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LCP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCPFluorescent DyeLo phasescancerGUV membrane modelslysosomesHeLa cellsLd phasesplasma membraneLysoTracker Reddrug-induced apoptosiscisplatinInhibitorinhibitorinhibit

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