2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation PI3K/Akt/mTOR
  3. nAChR Interleukin Related Akt
  4. Lemairamin

Lemairamin (Wgx-50) 是一种羟胺类化合物。Lemairamin 可从花椒属 (Zanthoxylum) 植物的果皮中分离得到。Lemairamin 可激活 α7nAChR，促进 IL-10 和 POMC 的表达。Lemairamin 可使 Akt 水平降低。Lemairamin 可减轻 DSS 诱导的肠道炎症。Lemairamin 可缓解痛觉过敏。

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Lemairamin

Lemairamin Chemical Structure

CAS No. : 29946-61-0

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Lemairamin 相关抗体

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity[1][2].

IC50 & Target[2][1]

IL-10

 

IL-6

 

IL-1β

 

体外研究
(In Vitro)

Lemairamin (10 μM; 2 h) 可刺激原代大鼠脊髓小胶质细胞中 IL-10 和 POMC 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lemairamin 相关抗体:
体内研究
(In Vivo)

Lemairamin (Wgx-50) (10 μL/L；6-18 h) 在 DSS 诱导的炎症性肠病斑马鱼模型中呈现出剂量-时间依赖性的抗炎作用[1]。
Lemairamin (1-300 mg/kg；皮下注射) 可剂量依赖性地抑制雄性 Swiss 小鼠中福尔马林诱导的强直性疼痛，其 Emax 为 66.7% 抑制率，ED50 为 11.1 mg/kg[2]。
Lemairamin (1-300 mg/kg; s.c.; single administration) 可剂量依赖性地抑制成年 Wistar 大鼠中福尔马林诱导的强直性疼痛，其 Emax 为 45.9% 抑制率，ED50 为 21.9 mg/kg[2]。
Lemairamin (10-300 μg；鞘内注射) 剂量依赖性减轻 L5/L6 脊神经结扎的 Wistar 大鼠同侧后爪的机械性痛觉超敏，其 Emax 为 60.4% MPE，ED50 为 83.9 μg[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type (WT); Tg(lyz:EGFP) (transgenic for neutrophil labeling; 3-day-post-fertilization; DSS-induced intestinal inflammation)[1]
Dosage: 10 μL/L
Administration: 6, 12, or 18 hours
Result: Suppressed recruitment of neutrophils to the intestinal injury site, with the most significant reduction observed at 12 hours.
Significantly reduced the relative mRNA expression levels of pro-inflammatory cytokines il-1β, il-6, cxcl8a, and tnf-α, with the most significant reduction at 12 hours.
Preserved intestinal morphology, including intact, well-arranged intestinal epithelial cell structure, normal glandular structure, reduced intestinal vacuoles, alleviated DSS-induced increases in crypt depth, and restored the villus length to crypt depth ratio.
Significantly decreased the relative protein expression of p-Akt/Akt compared to the DSS-only group.
Significantly downregulated the relative mRNA expression levels of akt1, akt2, and akt3, which were upregulated by DSS treatment.
分子量

311.37

Formula

C19H21NO3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lemairamin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lemairamin29946-61-0Wgx-50Wgx50Wgx 50nAChRInterleukin RelatedAktNicotinic acetylcholine receptorsILPKBProtein kinase BAlzheimer's diseaseneutrophilinflammatory bowel diseasezebrafishprimary spinal microglial cellα7 nicotinic acetylcholine receptorAkt pathwaypro-inflammatory cytokineβ-endorphinIL-10Inhibitorinhibitorinhibit

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