2. Anti-infection
  3. Bacterial
  4. LpxC-IN-17

LpxC-IN-17 (Compound a5) 是一种非共价 LpxC 抑制剂和抗菌 (Antibacterial) 剂。LpxC-IN-17 可螯合催化锌离子，并在 LpxC 活性位点内形成广泛的非共价相互作用，从而在功能上抑制该酶。LpxC-IN-17 对包括大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌在内的革兰氏阴性病原体具有抗菌活性。LpxC-IN-17 可用于革兰氏阴性细菌感染的相关研究。

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LpxC-IN-17

LpxC-IN-17 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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LpxC-IN-17 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LpxC-IN-17 (Compound a5) is a non-covalent LpxC inhibitor and Antibacterial agent. LpxC-IN-17 chelates catalytic zinc ions and forms extensive non-covalent interactions within the LpxC active site, thereby functionally inhibiting the enzyme. LpxC-IN-17 exhibits antibacterial activity against Gram-negative pathogens including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. LpxC-IN-17 is applicable to research related to Gram-negative bacterial infections[1].

体外研究
(In Vitro)

LpxC-IN-17 对大肠杆菌 (MICs: 0.06-0.25 μg/mL)、肺炎克雷伯菌 (MICs: 1-16 μg/mL) 和铜绿假单胞菌 (MICs: 1-4 μg/mL) 表现出显著的抗菌活性。[1]。
LpxC-IN-17 对 A549 和 HepG2 细胞表现出低细胞毒性 (IC50 >10 μM)，对 HEK293 细胞表现出中等细胞毒性 (IC50 = 2.260 ± 0.8583 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LpxC-IN-17 相关抗体:
分子量

403.43

Formula

C22H21N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LpxC-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LpxC-IN-17BacterialUDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylasegram-negative bacterial infectionsEscherichia coliLpxCPseudomonas aeruginosaHepG2HEK293Gram-negative pathogensKlebsiella pneumoniaeA549Inhibitorinhibitorinhibit

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目录号：
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