2. Anti-infection
  3. Bacterial
  4. LpxH-IN-3

LpxH-IN-3 是一种肺炎克雷伯菌 (Klebsiella pneumoniae) LpxH 抑制剂，其 IC50 为 0.17 μM。LpxH-IN-3 可与肺炎克雷伯菌 LpxH 的 L 型疏水结合口袋结合，与关键残基形成氢键及其他相互作用，破坏脂质 A 的生物合成并诱导细菌死亡。LpxH-IN-3 对肺炎克雷伯菌和大肠杆菌表现出中等抗菌活性。LpxH-IN-3 可用于肺炎克雷伯菌感染的相关研究。

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LpxH-IN-3

LpxH-IN-3 Chemical Structure

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LpxH-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LpxH-IN-3 is a Klebsiella pneumoniae LpxH inhibitor with an IC50 of 0.17 μM. LpxH-IN-3 binds to the L-shaped hydrophobic binding pocket of Klebsiella pneumoniae LpxH, forms hydrogen bonds and other interactions with key residues, disrupts lipid A biosynthesis, and induces bacterial death. LpxH-IN-3 exhibits moderate antibacterial activity against Klebsiella pneumoniae and Escherichia coli. LpxH-IN-3 can be used for the research of klebsiella pneumoniae infection[1].

体外研究
(In Vitro)

LpxH-IN-3 (Compound 7) (0.0001-100 μM; 1 μM) 可强效抑制纯化的肺炎克雷伯菌 LpxH，其 IC50 为 0.17 μM，在 1 μM 浓度下抑制率达 81%[1]。
LpxH-IN-3 (0.06-128 μg/mL; 18-24 h) 对野生型肺炎克雷伯菌 ATCC 10031 表现出中等抗菌活性，其 MIC 为 5.3 μg/mL；而对胞外膜缺陷型和外排缺陷型大肠杆菌突变株的活性更强，对应的 MIC 分别为 0.25 μg/mL 和 0.5 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LpxH-IN-3 相关抗体:
分子量

575.51

Formula

C27H28Cl2N4O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LpxH-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LpxH-IN-3Bacterialefflux-defective mutantsATCC 10031LpxHlipid A biosynthesiscocrystal structureEscherichia coliKlebsiella pneumoniaeouter membrane-defective mutantsInhibitorinhibitorinhibit

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目录号：
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