2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. LY 178210

LY 178210 (Compound 24) 是一种选择性的 5-羟色胺 1A 受体 (5-HT1A receptor) 部分激动剂，其对 5-HT1A 受体和 5-HT1D 受体的 Ki 分别为 0.67 和 380 nM。LY 178210 对 α₂-肾上腺素能受体、5-HT₂ 等神经递质受体几乎无活性。LY 178210 抑制 Foscolin 刺激的环化酶活性，但最大效能低于完全激动剂 8-OH-DPAT (HY-112061)。LY 178210 显著降低大下丘脑 5-羟基吲哚乙酸 (5-HIAA) 水平并提升了血清皮质酮浓度。

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LY 178210

LY 178210 Chemical Structure

CAS No. : 114943-19-0

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LY 178210 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values ​​of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061). LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations[1][2].

IC50 & Target[1]

5-HT1A Receptor

0.67 nM (IC50)

5-HT1D Receptor

380 nM (IC50)

分子量

299.41

Formula

C18H25N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY 178210 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 178210114943-19-0LY178210LY-1782105-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1A receptorpartial agonisttricyclic ergolineradioligand bindingadenylate cyclaseselectivitycarboxamide substitutionserotonin agoniststructure-activity relationshipInhibitorinhibitorinhibit

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目录号：
HY-129481
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