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  4. M1219

M1219 是一种 GSH/ATP 双近红外激活荧光探针，可无光谱串扰地独立实时监测细胞内 GSH 和 ATP 动态变化 (GSH: Ex=640 nm，Em=740~800 nm; ATP: Ex=594 nm/610 nm，Em=650~700 nm)。M1219 不仅能可视化 SLC7A11/GLUT1 单/双靶点抑制下 TNBC 的代谢调控机制并精准评估其体内疗效，还能实现 TNBC 肿瘤浸润边界的精准定位。M1219 可用于三阴性乳腺癌的研究。

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M1219

M1219 Chemical Structure

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M1219 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

M1219 is a GSH/ATP dual near-infrared activated fluorescent probe that enables independent real-time monitoring of dynamic changes in intracellular GSH and ATP without spectral crosstalk (GSH: Ex=640 nm, Em=740~800 nm; ATP: Ex=594 nm/610 nm, Em=650~700 nm). M1219 not only visualizes the metabolic regulatory mechanism of TNBC under single/dual-target inhibition of SLC7A11/GLUT1 and accurately evaluates its in vivo efficacy, but also achieves precise localization of the TNBC tumor invasion boundary. M1219 can be used for the research of triple-negative breast cancer[1].

体外研究
(In Vitro)

M1219 (0-24 h) 是一种双功能近红外荧光探针，可在无细胞缓冲液体系中特异性、稳定且独立地检测 GSH 和 ATP，其检测范围与生理浓度匹配，针对 GSH 的 EC50 值为 6.711 mM，针对 ATP 的 EC50 值为 4.108 mM[1]。
M1219 (20 μM; 15 min) 可特异性且独立地检测活 4T1 细胞中的内源性 GSH 与 ATP，从而实现可视化氧化还原及能量代谢调节剂作用下这些分子的动态变化[1]。
M1219 (15-60 分钟) 可在乳腺癌标本中实现高对比度荧光成像，用于精准识别肿瘤边界，从而准确区分癌组织与邻近组织[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

M1219 相关抗体:
体内研究
(In Vivo)

M1219 (0.5 mmol in 200 μL；3 次；静脉注射) 可在原位三阴性乳腺癌 (TNBC) 小鼠模型中实现谷胱甘肽 (GSH) 和三磷酸腺苷 (ATP) 动态变化的实时双通道近红外可视化，且荧光信号强度与治疗效果呈显著负相关[1]。
M1219 (瘤内注射) 可实现小鼠皮下三阴性乳腺癌 (TNBC) 肿瘤的精准近红外荧光引导切除，通过肿瘤与正常组织的高对比度区分，获得<0.1 mm 的阴性切缘[1]。
M1219 (1 mmol in 100 μL；静脉注射；给药后观察 24 小时) 在健康 BALB/c 小鼠中表现出低体内毒性与良好的生物安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female)[1]
Dosage: 0.5 mmol in 200 μL
Administration: tail vein injection; on days 0, 10, and 18 post-treatment initiation
Result: Showed similar dual-channel (GSH at 815 nm, ATP at 650 nm) fluorescence intensities in tumor regions across all treatment groups on day 0.
Reached GSH channel fluorescence intensity 0.091-fold of the PBS control group, and ATP channel fluorescence intensity 0.090-fold of the control group in tumors by day 18.
Confirmed ex vivo GSH and ATP channel fluorescence intensities of 0.1067-fold and 0.093-fold of the control group, respectively.
Demonstrated a significant negative correlation between fluorescence signal intensity and tumor growth inhibition and therapeutic efficacy.
分子量

1256.04

Formula

C76H83ClN8O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

M1219 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M1219M 1219M-1219Fluorescent Dyeoxidative stressATPTNBCmouse modelsGSH4T1 cellstriple-negative breast cancerbreast cancermitochondriaInhibitorinhibitorinhibit

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