2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Magnocurarine chloride

Magnocurarine chloride 是一种神经肌肉接头阻滞剂，通过功能性阻断信号传递来抑制肌肉收缩，且不直接损伤神经或肌肉组织。在青蛙、小鼠和家兔模型中，Magnocurarine chloride 表现出剂量依赖性的麻痹效应，从肢体无力、翻正反射丧失逐渐发展为呼吸抑制乃至心脏停搏。尽管高剂量会导致运动完全停止，但 Magnocurarine chloride 并不影响青蛙的脊髓多神经元反射。Magnocurarine chloride 在多种动物模型中展现出与筒箭毒碱 (HY-125901) 类似的生物活性。

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Magnocurarine chloride

Magnocurarine chloride Chemical Structure

CAS No. : 75413-87-5

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Other Forms of Magnocurarine chloride:

Magnocurarine chloride 相关抗体

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  • 生物活性

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生物活性

Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models[1][2].

体内研究
(In Vivo)

Magnocurarine chloride (0.25-1 mg/10g; 腹侧淋巴囊注射; 单剂量) 可在青蛙中产生剂量依赖性神经肌肉麻痹，0.75 mg/10g 剂量下会出现完全呼吸麻痹 (持续 165 min)，而 1 mg/10g 剂量下对脊髓多神经元反射无影响[1]。
Magnocurarine chloride (5-15.63 mg/kg; i.v.; 单剂量) 在 urethane (HY-B1207) 麻醉的家兔中可产生剂量依赖性的神经肌肉阻滞和呼吸作用，15 mg/kg 剂量下会出现完全肌肉麻痹和呼吸停止，且动物可在 25-30 min 内完全恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: autumn-collected frogs[1]
Dosage: 0.25 mg/10g; 0.5 mg/10g; 0.75 mg/10g; 1.0 mg/10g; 1 mg/10g
Administration: ventral lymph sac; single dose
Result: Slowed but did not abolish the righting reaction at 0.25 mg/10g.
Abolished the righting reaction while retaining weak skin reflexes and visible respiratory movements at 0.5 mg/10g.
Stopped all movements including respiration, with paralysis persisting for 165 minutes at 0.75 mg/10g.
Caused full paralysis persisting for 330 minutes at 1.0 mg/10g.
Completely blocked gastrocnemius muscle contraction in response to sciatic nerve stimulation by 25 minutes post-injection in unligated legs at 0.75 mg/10g, while ligated (drug-free) legs retained responsiveness.
Did not depress the spinal multineuron reflex at 1 mg/10g, as the drug-free ligated leg's gastrocnemius muscle still contracted in response to sciatic nerve stimulation after full limb paralysis.
Animal Model: Rabbit (2.0-2.5 kg; urethane-anesthetized)[1]
Dosage: 15.63 mg/kg (head drop); 5 mg/kg; 10 mg/kg; 15 mg/kg
Administration: i.v.; single dose (over 5 seconds); i.v.; 2 mg/15 sec infusion
Result: Produced head drop at 15.63 mg/kg (delivered as 2 mg/15 sec).
Decreased gastrocnemius muscle contraction intensity for 5-8 minutes, caused early respiratory depression followed by stimulation lasting 8-10 minutes at 5 mg/kg.
Caused more marked inhibition of muscle twitch and respiratory effects with longer duration than the 5 mg/kg dose at 10 mg/kg.
Completely abolished gastrocnemius muscle contraction within 1 minute, ceased respiratory movements, with recovery of muscle response and spontaneous respiration starting at 7-8 minutes post-injection, and full recovery within 25-30 minutes at 15 mg/kg.
分子量

349.85

Formula

C19H24ClNO3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Magnocurarine chloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magnocurarine75413-87-5nAChRNicotinic acetylcholine receptorsurethane-anesthetized rabbitsrabbitsnerve stimulationmicerespiratory arrestneuromuscular junctionmuscle contractionrabbit gastrocnemius musclespinal multineuron reflexesfrogsInhibitorinhibitorinhibit

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