2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Manoalogue

Manoalogue 是一种不可逆的分泌型磷脂酶 A2 (sPLA2) 抑制剂。Manoalogue 可共价修饰蜂毒磷脂酶 A2 (bvPLA2) 的 K94 位点以灭活该酶，并对 bvPLA2 表现出选择性抑制作用。Manoalogue 能够抑制 PLA2 介导的豚鼠肺胸膜条收缩。Manoalogue 可用于 sPLA2 作用机制及呼吸生理学研究。

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Manoalogue

Manoalogue Chemical Structure

CAS No. : 136440-42-1

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Manoalogue 相关抗体

Top Publications Citing Use of Products

查看 Phospholipase 亚型特异性产品:

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Phospholipase A PLD Phospholipase C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Manoalogue is an irreversible secretory phospholipase A2 (sPLA2) inhibitor. Manoalogue covalently modifies K94 of bee venom phospholipase A2 (bvPLA2) to inactivate the enzyme and shows selective inhibition on bvPLA2. Manoalogue can suppress PLA2-mediated contractions of guinea pig lung pleural strips. Manoalogue is used for sPLA2 mechanism and respiratory physiology research[1][2].

IC50 & Target[1]

sPLA2

 

体外研究
(In Vitro)

Manoalogue (摩尔比 manoalogue/bvPLA2 = 20；20-120 min) 可通过共价修饰赖氨酸 94 (K94) 使野生型 bvPLA2 及大多数赖氨酸-谷氨酸 bvPLA2 突变体失活，而 K94E 突变体对该失活作用完全耐受，K85E 突变体则表现出轻微耐受性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Manoalogue 相关抗体:
体内研究
(In Vivo)

Manoalogue (预孵育 24 小时) 可显著抑制 PLA2 诱导的豚鼠肺胸膜条收缩[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

318.41

Formula

C19H26O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Manoalogue 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manoalogue136440-42-1PhospholipasebvPLA2guinea pig lung pleural stripsbee venom phospholipase A2K85E mutantwild-type bvPLA2PLA2secretory phospholipase A2K94E mutantlysine residue K94lysine-to-glutamate bvPLA2 mutantsInhibitorinhibitorinhibit

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目录号：
HY-182680
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