2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-53

MAO-B-IN-53 是一种人单胺氧化酶 B (hMAO-B) 抑制剂，其 IC50 为 0.066 μM。MAO-B-IN-53 表现出混合型可逆抑制作用，能稳定结合 hMAO-B 的活性位点，且对 hMAO-A 具有高选择性。MAO-B-IN-53 可作为神经保护剂，抵御 6-OHDA (HY-B1081) 诱导的损伤，且在神经母细胞瘤细胞中表现出低神经毒性。MAO-B-IN-53 可用于帕金森病的研究。

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MAO-B-IN-53

MAO-B-IN-53 Chemical Structure

CAS No. : 3069131-62-7

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MAO-B-IN-53 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-53 is a human monoamine oxidase B (hMAO-B) inhibitor with an IC50 of 0.066 μM. MAO-B-IN-53 exhibits mixed reversible inhibition, binds stably to the hMAO-B active site, and shows high selectivity over hMAO-A. MAO-B-IN-53 acts as a neuroprotective agent, protects against 6-OHDA-induced damage, and exhibits low neurotoxicity in neuroblastoma cells. MAO-B-IN-53 can be used for the research of Parkinson's disease[1].

IC50 & Target[1]

hMAO-B

66 nM ()

体外研究
(In Vitro)

MAO-B-IN-53 (Compound 8) (1.25-10 μM; 24 h) 对 SH-SY5Y 细胞表现出低细胞毒性，在孵育 24 小时后，浓度高达 10 μM 时细胞存活率仍≥86.5%[1]。
MAO-B-IN-53 (1.25-5 μM; 25 h) 在 SH-SY5Y 细胞中对 6-OHDA 诱导的损伤表现出显著的神经保护作用，在 1.25 μM 时细胞存活率可达最大值 70.0%[1]。
MAO-B-IN-53 (1.25-2.5 μM; 24 h) 具有体外抗氧化活性，在浓度高达 2.5 μM 时，不会升高 SH-SY5Y 细胞内的 ROS 水平，也不会诱导其产生氧化损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-53 相关抗体:
分子量

327.37

Formula

C20H19F2NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-53 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-533069131-62-7Monoamine OxidaseMAOSH-SY5Y cellshuman monoamine oxidase B6-OHDAneuroblastoma cellsneuroprotective agentParkinson's diseasehMAO-AhMAO-BInhibitorinhibitorinhibit

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