2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Monoamine Oxidase Amyloid-β Reactive Oxygen Species (ROS)
  4. MAO-B-IN-54

MAO-B-IN-54 是一种选择性、可逆的竞争性单胺氧化酶 B (MAOB) 抑制剂，对人源靶点的 IC50 为 0.052 μM，Ki 为 0.028 μM。MAO-B-IN-54 对 MAOA 的活性较弱。MAO-B-IN-54 可同时占据 MAOB 的入口腔和底物腔，形成疏水相互作用和氢键相互作用。MAO-B-IN-54 可抑制 Aβ 聚集与 ROS 的产生。MAO-B-IN-54 可用于阿尔茨海默病的研究。

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MAO-B-IN-54

MAO-B-IN-54 Chemical Structure

CAS No. : 52688-60-5

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MAO-B-IN-54 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease[1].

IC50 & Target[1]

hMAO-B

0.052 μM (IC50)

hMAO-A

0.67 μM (IC50)

hMAO-B

0.028 μM (Ki)

hMAO-A

0.19 μM (Ki)

体外研究
(In Vitro)

MAO-B-IN-54 (Compound L2-b) (0-60 min) 可以可逆方式强效且竞争性地抑制重组人源 MAO-B 和 MAO-A，其 IC50 为 0.052 和 0.67 μM、Ki 为 0.028 和 0.19 μM，并且能结合该酶的入口腔和底物腔[1]。
MAO-B-IN-54 可调控金属相关的 β-淀粉样蛋白 (Aβ) 物种，抑制金属诱导的 Aβ 聚集、神经毒性以及活性氧 (ROS) 的产生。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-54 相关抗体:
分子量

227.31

Formula

C14H17N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-54 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-5452688-60-5Monoamine OxidaseAmyloid-βReactive Oxygen Species (ROS)MAOβ-amyloid peptideAβAbetaMAOBMAOAreactive oxygen speciesAlzheimer’s diseasemonoamine oxidase BParkinson’s diseaseamyloid-betaROSInhibitorinhibitorinhibit

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