2. Neuronal Signaling Immunology/Inflammation
  3. Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX Amyloid-β
  4. MAO-B-IN-56

MAO-B-IN-56 是一种具有 AChE、BChE、MAO-A、MAO-B、BACE1 和 COX-2 抑制活性的多靶点抑制剂，其 IC50 值分别为 0.35 μM、3.22 μM、0.85 μM、0.14 μM、3.85 μM 和 7.83 μM。MAO-B-IN-56 可减少 β-淀粉样蛋白生成、减轻爪水肿、改善空间记忆，并改善阿尔茨海默病的病理特征及相关组织病理学改变。MAO-B-IN-56 可用于阿尔茨海默病的研究。

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MAO-B-IN-56

MAO-B-IN-56 Chemical Structure

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MAO-B-IN-56 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-56 is a multi-target-directed ligand with AChE, BChE, MAO-B, and BACE1 inhibitory activity, with IC50 values of 0.35 μM, 3.22 μM, 0.14 μM, and 3.85 μM respectively, and shows selectivity for AChE over BChE and MAO-B over MAO-A.MAO-B-IN-56 reduces amyloid-beta production, reduces paw edema, improves spatial memory, and enhances Alzheimer's disease hallmarks and associated histopathological alterations.MAO-B-IN-56 can be used for the research of alzheimer's disease[1].

IC50 & Target[1]

AChE

0.35 μM (IC50)

BChE

1.55 μM (IC50)

BACE1

3.85 μM (IC50)

MAO-A

0.85 μM (IC50)

MAO-B

0.14 μM (IC50)

COX-2

7.83 μM (IC50)

体外研究
(In Vitro)

MAO-B-IN-56 (Compound 3k) 对 AChE 的选择性高于 BChE，对 MAO-B 的选择性高于 MAO-A[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-56 相关抗体:
体内研究
(In Vivo)

MAO-B-IN-56 (Compound 3k) (0.028 mmol/kg；单次给药) 显示出强效抗炎活性，在诱导后 2 h 可将角叉菜胶诱导的大鼠足爪水肿降低 88.88%[1]。
MAO-B-IN-56 (0.026 mmol/kg，每日给药) 可有效改善链脲佐菌素 (STZ) (HY-13753) 诱导的小鼠阿尔茨海默病病理，提升空间记忆能力、维持海马结构完整性，并使阿尔茨海默病 (AD) 相关关键生化指标恢复正常，但无法恢复新物体识别 (NOR) 实验中的识别记忆指标[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

534.59

Formula

C26H26N6O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-56 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-56Cholinesterase (ChE)Monoamine OxidaseBeta-secretaseCOXAmyloid-βMAOBACEβ-Secretase Cyclooxygenaseβ-amyloid peptideAβAbetaCOX-2AChEBChEMAO-Aamyloid-betahippocampal architectureBACE1MAO-BSTZ-induced Alzheimer's disease pathologycarrageenan-induced rat paw edemaInhibitorinhibitorinhibit

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