2. Anti-infection
  3. Bacterial
  4. MC-207110

MC-207110 是一种广谱外排泵抑制剂。MC-207110 对铜绿假单胞菌 (P. aeruginosa) 的所有三种已知 Mex 外排泵及其亲缘关系较近的大肠杆菌 (Escherichia coli) 外排泵同源物 (AcrAB-TolC) 均有活性。MC-207110 能够降低铜绿假单胞菌 (P. aeruginosa) 对氟喹诺酮类药物的固有耐药性。MC-207110 可用于感染方面的研究。

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CAS No. : 115871-02-8

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MC-207110 相关抗体

Top Publications Citing Use of Products

    MC-207110 purchased from MCE. Usage Cited in: Cell Rep. 2025 Jul 22;44(7):115987.  [Abstract]

    Effect of efflux pump inhibitors (CCCP (10 mg/L), NMP (25 mg/L ), and PAβN dihydrochloride (25 mg/L)) on the susceptibility of evolved strains to tigecycline (n = 2). PAβN dihydrochloride lowered the MIC values and reversed the tigecycline-resistance phenotypes, suggesting a role for increased efflux pump activity in tigecycline resistance.

    MC-207110 purchased from MCE. Usage Cited in: Front Microbiol. 2024 Sep 24:15:1417237.  [Abstract]

    The results of tigecycline combined with PAβN dihydrochloride (20 mg/L) demonstrated that 20 TNSKP strains exhibited a fold decrease ≥ 4 in MIC after co-incubation with PAβN, but 2 strains of TSKP did not show any change in MIC under the effect of efflux pump inhibitor.

    MC-207110 purchased from MCE. Usage Cited in: Microb Pathog. 2023 Dec:185:106397.  [Abstract]

    PAβN dihydrochloride (50 μg/mL; 50 μL; 24 h)。 Results of screening test strains.

    MC-207110 purchased from MCE. Usage Cited in: Front Cell Infect Microbiol. 2021 Mar 25;11:660431.  [Abstract]

    BBH uptake with pump inhibitors CCCP, PAβN dihydrochloride (50 µM; 60 min), and reserpine in ATCC 19606 strain, MDR-B and △adeB MDR-B strains, and MDR-TJ and △adeB MDR-TJ strains. Red arrows indicate the pump inhibitors (50 µM) were added at 60 min. Grey letters indicate the inhibitors were added to the adeB knockout strains.

    MC-207110 purchased from MCE. Usage Cited in: Microb Drug Resist. 2020 Jun;26(6):550-560.  [Abstract]

    PAβN dihydrochloride (50-200 μg/mL) and NMP inhibited OqxB activity in a concentration-dependent manner, suggesting that an efflux pump (OqxAB) is indeed responsible for the decreased susceptibility of the overexpression system.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    MC-207110 is a broad-spectrum efflux pump inhibitor. MC-207110 is active against all three known Mex efflux pumps from P. aeruginosa and their close Escherichia coli efflux pump homolog (AcrAB-TolC). MC-207110 can decrease the intrinsic resistance of P. aeruginosa to fluoroquinolones. MC-207110 can be used for the research of infection [1].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    HEK293 CC50
    > 100 μM
    Compound: PAbetaN
    Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay
    Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay
    		[PMID: 37672933]
    LX-2 CC50
    > 100 μM
    Compound: PAbetaN
    Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay
    Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay
    		[PMID: 37672933]
    分子量

    446.54

    Formula

    C25H30N6O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    MC-207110 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MC-207110115871-02-8MC207110MC 207110Bacterialefflux pumpMexP. aeruginosaEscherichia coliAcrAB-TolCfluoroquinolonesinfectionInhibitorinhibitorinhibit

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    目录号：
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