2. Academic Validation
  3. LFA-1 and ICAM-1 antibody-idarubicin conjugates separately prolong murine cardiac allograft survival

LFA-1 and ICAM-1 antibody-idarubicin conjugates separately prolong murine cardiac allograft survival

  • Transpl Immunol. 2001 Oct;9(1):7-11. doi: 10.1016/s0966-3274(01)00038-7.
G A Pietersz 1,  M S Sandrin,  S Ling,  Y Q Li,  McKenzie IFC
Affiliations

Affiliation

  • 1 The Austin Research Institute, Heidelberg, Victoria, Australia. g.pietersz@ari.unimelb.edu.au
PMID: 11680574 DOI: 10.1016/s0966-3274(01)00038-7
Abstract

Drug antibody conjugates can enhance the activity of monoclonal antibodies (MoAb) and idarubicin-MoAb conjugates have led to tolerance induction with antibodies which are inactive when used alone. It has been reported that, in mice, antibodies to ICAM-1 and LFA-1 have to be used together to induce tolerance to cardiac allografts; here we show that these monoclonal antibodies, conjugated to idarubicin, can lead to tolerance induction to cardiac allografts when used alone.

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