2. Academic Validation
  3. Pi-delocalized beta-carbolinium cations as potential antimalarials

Pi-delocalized beta-carbolinium cations as potential antimalarials

  • Bioorg Med Chem Lett. 2004 Apr 5;14(7):1689-92. doi: 10.1016/j.bmcl.2004.01.055.
Kiyosei Takasu 1,  Tsubasa Shimogama,  Chalerm Saiin,  Hye-Sook Kim,  Yusuke Wataya,  Masataka Ihara
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. kay-t@mail.pharm.tohoku.ac.jp
PMID: 15026051 DOI: 10.1016/j.bmcl.2004.01.055
Abstract

Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.

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