2. Academic Validation
  3. Full orthogonality between Dde and Fmoc: the direct synthesis of PNA--peptide conjugates

Full orthogonality between Dde and Fmoc: the direct synthesis of PNA--peptide conjugates

  • Org Lett. 2004 Apr 1;6(7):1127-9. doi: 10.1021/ol049905y.
Juan Jose Díaz-Mochón 1,  Laurent Bialy,  Mark Bradley
Affiliations

Affiliation

  • 1 School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
PMID: 15040739 DOI: 10.1021/ol049905y
Abstract

New deprotection conditions for the Dde amine protecting group that are fully orthogonal to Fmoc are described and successfully applied to the dual synthesis of PNA-peptide conjugates.

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