2. Academic Validation
  3. Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species

Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species

  • J Nat Prod. 2004 Aug;67(8):1262-7. doi: 10.1021/np034077n.
Tadashi Endo 1,  Masashi Tsuda,  Tadashi Okada,  Shinya Mitsuhashi,  Hiroshi Shima,  Kunimi Kikuchi,  Yuzuru Mikami,  Jane Fromont,  Jun'ichi Kobayashi
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
PMID: 15332839 DOI: 10.1021/np034077n
Abstract

Eight new dimeric bromopyrrole Alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10-dihydrokeramadine (9), have been isolated from the Okinawan marine Sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited Antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein Phosphatase 2A activity.

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